Current Opinion in Chemical Biology

, volume 74 , pages 102303

Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands

Zhiqin Deng ^{1, 2}

Guangyu Zhu ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

City University of Hong Kong Shenzhen Research Institute, Shenzhen, 518057, PR China |

Department of Chemistry, City University of Hong Kong, Hong Kong SAR, PR China |

Publication type: Journal Article

Publication date: 2023-06-01

Elsevier

Current Opinion in Chemical Biology

scimago Q1

wos Q1

SJR: 2.057

CiteScore: 12.7

Impact factor: 6.1

ISSN: 13675931, 18790402

DOI: 10.1016/j.cbpa.2023.102303

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PubMed ID: 37075513

Biochemistry

Analytical Chemistry

Abstract

The clinical application of Pt-based anticancer drugs has inspired the development of novel chemotherapeutic metallodrugs with improved efficacies. Pt(IV) prodrugs are one of the most promising successors of Pt(II) drugs and have displayed great anticancer performance. In particular, judicious modification of axial ligands endows Pt(IV) complexes with unique properties that enable them to overcome the limitations of conventional Pt(II) drugs. Herein, we summarize recent developments in Pt(IV) anticancer complexes, with a focus on their axial functionalization with other anticancer agents, immunotherapeutic agents, photosensitive ligands, peptides, and theranostic agents. We hope that this concise view of recently reported Pt(IV) coordination complexes will help researchers to design next-generation multi-functional anticancer agents based on a comprehensive Pt(IV) platform.

Found

1 citation

Mazur Dmitrii

🤝

PhD in Chemistry

67 publications, 787 citations, 3 reviews

h-index: 19

Lomonosov Moscow State University

Shenzhen MSU-BIT University

Research interests

Astrochemistry

Bioorganic chemistry

Disinfection of water

Ecology

Environmental Chemistry

Environmental Science

Mass Spectrometry

Organic Chemistry

Peptides

Synthetic Organic Chemistry

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GOST Copy

Deng Z. et al. Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands // Current Opinion in Chemical Biology. 2023. Vol. 74. p. 102303.

GOST all authors (up to 50) Copy

Deng Z., Zhu G. Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands // Current Opinion in Chemical Biology. 2023. Vol. 74. p. 102303.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.cbpa.2023.102303

UR - https://doi.org/10.1016/j.cbpa.2023.102303

TI - Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands

T2 - Current Opinion in Chemical Biology

AU - Deng, Zhiqin

AU - Zhu, Guangyu

PY - 2023

DA - 2023/06/01

PB - Elsevier

SP - 102303

VL - 74

PMID - 37075513

SN - 1367-5931

SN - 1879-0402

ER -

BibTex

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BibTex (up to 50 authors) Copy

@article{2023_Deng,

author = {Zhiqin Deng and Guangyu Zhu},

title = {Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands},

journal = {Current Opinion in Chemical Biology},

year = {2023},

volume = {74},

publisher = {Elsevier},

month = {jun},

url = {https://doi.org/10.1016/j.cbpa.2023.102303},

pages = {102303},

doi = {10.1016/j.cbpa.2023.102303}

}

Publisher

Elsevier

Journal

Current Opinion in Chemical Biology

scimago Q1

wos Q1

SJR

2.057

CiteScore

12.7

Impact factor

6.1

ISSN

13675931 (Print)

18790402 (Electronic)

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