Colloids and Surfaces B: Biointerfaces

, том 183 , страницы 110426

Anti-amyloid activities of three different types of water-soluble fullerene derivatives.

А. Г. Бобылёв ¹

Olga A Kraevaya ^{2, 3}

Ekaterina A Khakina ⁴

Roman S. Fadeev ¹

Alexander V Zhilenkov ⁴

Nikita V. Penkov ⁵

Ilia Y Teplov ⁵

И. М. Вихлянцев ¹

Pavel A. Troshin ^{2, 4}

Л. Г. Бобылёва ¹

Denis Mishchenko ⁴

Э. И. Якупова ¹

Скрыть аффилиации авторов Показать аффилиации авторов: 5 аффилиаций

Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya St. 3, Pushchino, Moscow Region, 142290, Russia |

Skolkovo Institute of Science and Technology, Nobel St. 3, Moscow, 143026, Russia |

Institute for Problems of Chemical Physics of the Russian Academy of Sciences, Semenov Prospect 1, Chernogolovka, 141432, Russia. |

⁴

Institute for Problems of Chemical Physics of the Russian Academy of Sciences, Semenov Prospect 1, Chernogolovka, 141432, Russia |

⁵

Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Institutskaya St., 3, Pushchino, Moscow Region, 142290, Russia.

Институт биофизики клетки РАН

ФИЦ "Пущинский научный центр биологических исследований" РАН

Тип публикации: Journal Article

Дата публикации: 2019-11-01

Elsevier

Colloids and Surfaces B: Biointerfaces

scimago Q1

wos Q1

БС1

SJR: 0.978

CiteScore: 11.8

Impact factor: 5.6

ISSN: 09277765, 18734367

DOI: 10.1016/j.colsurfb.2019.110426

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PubMed ID: 31421408

Physical and Theoretical Chemistry

General Medicine

Colloid and Surface Chemistry

Biotechnology

Surfaces and Interfaces

Краткое описание

Anti-amyloid activity, aggregation behaviour, cytotoxicity and acute toxicity were investigated for three water-soluble fullerene derivatives with different types of solubilizing addends. All investigated compounds showed a strong anti-amyloid effect in vitrocaused by interaction of the water-soluble fullerene derivatives with the Ab(1-42)-peptide and followed by destruction of the amyloid fibrils. Notably, all of the studied fullerene derivatives showed very low cytotoxicity and low acute toxicity in mice (most promising compound 3 was more than four times less toxic than aspirin). Strong anti-amyloid effect of the fullerene derivatives together with low toxicity reveals high potential of these compounds as drug candidates for treatment of neurodegenerative diseases.

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Бобылёв А. Г. et al. Anti-amyloid activities of three different types of water-soluble fullerene derivatives. // Colloids and Surfaces B: Biointerfaces. 2019. Vol. 183. p. 110426.

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Бобылёв А. Г., Kraevaya O. A., Khakina E. A., Fadeev R. S., Zhilenkov A. V., Penkov N. V., Teplov I. Y., Вихлянцев И. М., Troshin P. A., Бобылёва Л. Г., Mishchenko D., Якупова Э. И. Anti-amyloid activities of three different types of water-soluble fullerene derivatives. // Colloids and Surfaces B: Biointerfaces. 2019. Vol. 183. p. 110426.

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TY - JOUR

DO - 10.1016/j.colsurfb.2019.110426

UR - https://doi.org/10.1016/j.colsurfb.2019.110426

TI - Anti-amyloid activities of three different types of water-soluble fullerene derivatives.

T2 - Colloids and Surfaces B: Biointerfaces

AU - Бобылёв, А. Г.

AU - Kraevaya, Olga A

AU - Khakina, Ekaterina A

AU - Fadeev, Roman S.

AU - Zhilenkov, Alexander V

AU - Penkov, Nikita V.

AU - Teplov, Ilia Y

AU - Вихлянцев, И. М.

AU - Troshin, Pavel A.

AU - Бобылёва, Л. Г.

AU - Mishchenko, Denis

AU - Якупова, Э. И.

PY - 2019

DA - 2019/11/01

PB - Elsevier

SP - 110426

VL - 183

PMID - 31421408

SN - 0927-7765

SN - 1873-4367

ER -

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@article{2019_Бобылёв,

author = {А. Г. Бобылёв and Olga A Kraevaya and Ekaterina A Khakina and Roman S. Fadeev and Alexander V Zhilenkov and Nikita V. Penkov and Ilia Y Teplov and И. М. Вихлянцев and Pavel A. Troshin and Л. Г. Бобылёва and Denis Mishchenko and Э. И. Якупова},

title = {Anti-amyloid activities of three different types of water-soluble fullerene derivatives.},

journal = {Colloids and Surfaces B: Biointerfaces},

year = {2019},

volume = {183},

publisher = {Elsevier},

month = {nov},

url = {https://doi.org/10.1016/j.colsurfb.2019.110426},

pages = {110426},

doi = {10.1016/j.colsurfb.2019.110426}

}

Издатель

Elsevier

Журнал

Colloids and Surfaces B: Biointerfaces

scimago Q1

wos Q1

БС1

SJR

0.978

CiteScore

11.8

Impact factor

5.6

ISSN

09277765 (Print)

18734367 (Electronic)

Лаборатории

Лаборатория функциональных материалов для электроники и медицины

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