Colloids and Surfaces B: Biointerfaces

, volume 183 , pages 110426

Anti-amyloid activities of three different types of water-soluble fullerene derivatives.

А. Г. Бобылёв ¹

Olga A Kraevaya ^{2, 3}

Ekaterina A Khakina ⁴

Roman S. Fadeev ¹

Alexander V Zhilenkov ⁴

Nikita V. Penkov ⁵

Ilia Y Teplov ⁵

И. М. Вихлянцев ¹

Pavel A. Troshin ^{2, 4}

Л. Г. Бобылёва ¹

Denis Mishchenko ⁴

Э. И. Якупова ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya St. 3, Pushchino, Moscow Region, 142290, Russia |

Skolkovo Institute of Science and Technology, Nobel St. 3, Moscow, 143026, Russia |

Institute for Problems of Chemical Physics of the Russian Academy of Sciences, Semenov Prospect 1, Chernogolovka, 141432, Russia. |

⁴

Institute for Problems of Chemical Physics of the Russian Academy of Sciences, Semenov Prospect 1, Chernogolovka, 141432, Russia |

⁵

Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Institutskaya St., 3, Pushchino, Moscow Region, 142290, Russia.

Institute of Cell Biophysics of the Russian Academy of Sciences

Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences

Publication type: Journal Article

Publication date: 2019-11-01

Elsevier

Colloids and Surfaces B: Biointerfaces

scimago Q1

wos Q1

SJR: 0.978

CiteScore: 11.8

Impact factor: 5.6

ISSN: 09277765, 18734367

DOI: 10.1016/j.colsurfb.2019.110426

Copy DOI

PubMed ID: 31421408

Physical and Theoretical Chemistry

General Medicine

Colloid and Surface Chemistry

Biotechnology

Surfaces and Interfaces

Abstract

Anti-amyloid activity, aggregation behaviour, cytotoxicity and acute toxicity were investigated for three water-soluble fullerene derivatives with different types of solubilizing addends. All investigated compounds showed a strong anti-amyloid effect in vitrocaused by interaction of the water-soluble fullerene derivatives with the Ab(1-42)-peptide and followed by destruction of the amyloid fibrils. Notably, all of the studied fullerene derivatives showed very low cytotoxicity and low acute toxicity in mice (most promising compound 3 was more than four times less toxic than aspirin). Strong anti-amyloid effect of the fullerene derivatives together with low toxicity reveals high potential of these compounds as drug candidates for treatment of neurodegenerative diseases.

Found

1 citation

Kraevaya Olga

🥼 🤝

PhD in Chemistry

74 publications, 473 citations, 12 reviews

h-index: 12

Federal Research Center of Problem of Chemical Physics and Medicinal Chemistry RAS

1 citation

Fadeev Roman

PhD in Biological/biomedical sciences

63 publications, 645 citations

h-index: 16

Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences

Experimental oncology

1 citation

Ivankov Oleksandr

PhD in Physics and Mathematics

117 publications, 1 615 citations

h-index: 23

Joint Institute for Nuclear Research

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GOST Copy

Бобылёв А. Г. et al. Anti-amyloid activities of three different types of water-soluble fullerene derivatives. // Colloids and Surfaces B: Biointerfaces. 2019. Vol. 183. p. 110426.

GOST all authors (up to 50) Copy

Бобылёв А. Г., Kraevaya O. A., Khakina E. A., Fadeev R. S., Zhilenkov A. V., Penkov N. V., Teplov I. Y., Вихлянцев И. М., Troshin P. A., Бобылёва Л. Г., Mishchenko D., Якупова Э. И. Anti-amyloid activities of three different types of water-soluble fullerene derivatives. // Colloids and Surfaces B: Biointerfaces. 2019. Vol. 183. p. 110426.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.colsurfb.2019.110426

UR - https://doi.org/10.1016/j.colsurfb.2019.110426

TI - Anti-amyloid activities of three different types of water-soluble fullerene derivatives.

T2 - Colloids and Surfaces B: Biointerfaces

AU - Бобылёв, А. Г.

AU - Kraevaya, Olga A

AU - Khakina, Ekaterina A

AU - Fadeev, Roman S.

AU - Zhilenkov, Alexander V

AU - Penkov, Nikita V.

AU - Teplov, Ilia Y

AU - Вихлянцев, И. М.

AU - Troshin, Pavel A.

AU - Бобылёва, Л. Г.

AU - Mishchenko, Denis

AU - Якупова, Э. И.

PY - 2019

DA - 2019/11/01

PB - Elsevier

SP - 110426

VL - 183

PMID - 31421408

SN - 0927-7765

SN - 1873-4367

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Бобылёв,

author = {А. Г. Бобылёв and Olga A Kraevaya and Ekaterina A Khakina and Roman S. Fadeev and Alexander V Zhilenkov and Nikita V. Penkov and Ilia Y Teplov and И. М. Вихлянцев and Pavel A. Troshin and Л. Г. Бобылёва and Denis Mishchenko and Э. И. Якупова},

title = {Anti-amyloid activities of three different types of water-soluble fullerene derivatives.},

journal = {Colloids and Surfaces B: Biointerfaces},

year = {2019},

volume = {183},

publisher = {Elsevier},

month = {nov},

url = {https://doi.org/10.1016/j.colsurfb.2019.110426},

pages = {110426},

doi = {10.1016/j.colsurfb.2019.110426}

}

Publisher

Elsevier

Journal

Colloids and Surfaces B: Biointerfaces

scimago Q1

wos Q1

SJR

0.978

CiteScore

11.8

Impact factor

5.6

ISSN

09277765 (Print)

18734367 (Electronic)

Labs

Laboratory of Functional Materials for Electronics and Medicine

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