Small molecule inhibitors of ebola virus infection.
1
Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Str. 76a, 44227 Dortmund, Germany
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Publication type: Journal Article
Publication date: 2015-02-01
scimago Q1
wos Q1
SJR: 1.742
CiteScore: 16.0
Impact factor: 7.5
ISSN: 13596446, 18785832
PubMed ID:
25532798
Drug Discovery
Pharmacology
Abstract
• Ebola virus infection causes fulminant hemorrhagic fevers in humans with high lethality rates. • No approved treatment for ebola virus infection exists. • Antiviral research focusing on ebola virus is booming. • Approved drugs, clinical stage compounds, preclinical leads and chemical probes have shown anti-ebola virus activity. • We review >60 examples of small molecules with associated anti-ebola virus data. Ebola viruses are extremely virulent and highly transmissible. They are responsible for sporadic outbreaks of severe hemorrhagic fevers with human mortality rates of up to 90%. No prophylactic or therapeutic treatments in the form of vaccine, biologicals or small molecule, currently exist. Yet, a wealth of antiviral research on ebola virus is being generated and potential inhibitors have been identified in biological screening and medicinal chemistry programs. Here, we detail the state-of-the-art in small molecule inhibitors of ebola virus infection, with >60 examples, including approved drugs, compounds currently in clinical trials, and more exploratory leads, and summarize the associated in vitro and in vivo evidence for their effectiveness.
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GOST
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Picazo E., Giordanetto F. Small molecule inhibitors of ebola virus infection. // Drug Discovery Today. 2015. Vol. 20. No. 2. pp. 277-286.
GOST all authors (up to 50)
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Picazo E., Giordanetto F. Small molecule inhibitors of ebola virus infection. // Drug Discovery Today. 2015. Vol. 20. No. 2. pp. 277-286.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.drudis.2014.12.010
UR - https://doi.org/10.1016/j.drudis.2014.12.010
TI - Small molecule inhibitors of ebola virus infection.
T2 - Drug Discovery Today
AU - Picazo, Edwige
AU - Giordanetto, Fabrizio
PY - 2015
DA - 2015/02/01
PB - Elsevier
SP - 277-286
IS - 2
VL - 20
PMID - 25532798
SN - 1359-6446
SN - 1878-5832
ER -
Cite this
BibTex (up to 50 authors)
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@article{2015_Picazo,
author = {Edwige Picazo and Fabrizio Giordanetto},
title = {Small molecule inhibitors of ebola virus infection.},
journal = {Drug Discovery Today},
year = {2015},
volume = {20},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.drudis.2014.12.010},
number = {2},
pages = {277--286},
doi = {10.1016/j.drudis.2014.12.010}
}
Cite this
MLA
Copy
Picazo, Edwige, and Fabrizio Giordanetto. “Small molecule inhibitors of ebola virus infection..” Drug Discovery Today, vol. 20, no. 2, Feb. 2015, pp. 277-286. https://doi.org/10.1016/j.drudis.2014.12.010.