Synthesis and antimalarial activity of new atovaquone derivatives
Salomé El Hage
1
,
Michèle Ané
1
,
Jean-Luc Stigliani
1
,
Marjorie Maynadier
2
,
Henri VIAL
2
,
Geneviève Baziard-Mouysset
1
,
Marc Payard
1
2
Département Biologie Santé, UMR 5539, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
|
Publication type: Journal Article
Publication date: 2009-11-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
19747753
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
In this paper we describe the design and synthesis of 18 derivatives of the antimicrobial atovaquone which were substituted at the 3-hydroxy group by ester and ether functions. The compounds were evaluated in vitro for their activity against the growth of Plasmodium falciparum, the malaria causing parasite. All the compounds showed potent activity, with IC(50) values in the range of 1.25-50 nM, comparable to those of atovaquone and much higher than chloroquine or quinine.
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Total citations:
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Citations from 2025:
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MLA
Cite this
GOST
Copy
El Hage S. et al. Synthesis and antimalarial activity of new atovaquone derivatives // European Journal of Medicinal Chemistry. 2009. Vol. 44. No. 11. pp. 4778-4782.
GOST all authors (up to 50)
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El Hage S., Ané M., Stigliani J., Maynadier M., VIAL H., Baziard-Mouysset G., Payard M. Synthesis and antimalarial activity of new atovaquone derivatives // European Journal of Medicinal Chemistry. 2009. Vol. 44. No. 11. pp. 4778-4782.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ejmech.2009.07.021
UR - https://doi.org/10.1016/j.ejmech.2009.07.021
TI - Synthesis and antimalarial activity of new atovaquone derivatives
T2 - European Journal of Medicinal Chemistry
AU - El Hage, Salomé
AU - Ané, Michèle
AU - Stigliani, Jean-Luc
AU - Maynadier, Marjorie
AU - VIAL, Henri
AU - Baziard-Mouysset, Geneviève
AU - Payard, Marc
PY - 2009
DA - 2009/11/01
PB - Elsevier
SP - 4778-4782
IS - 11
VL - 44
PMID - 19747753
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2009_El Hage,
author = {Salomé El Hage and Michèle Ané and Jean-Luc Stigliani and Marjorie Maynadier and Henri VIAL and Geneviève Baziard-Mouysset and Marc Payard},
title = {Synthesis and antimalarial activity of new atovaquone derivatives},
journal = {European Journal of Medicinal Chemistry},
year = {2009},
volume = {44},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.ejmech.2009.07.021},
number = {11},
pages = {4778--4782},
doi = {10.1016/j.ejmech.2009.07.021}
}
Cite this
MLA
Copy
El Hage, Salomé, et al. “Synthesis and antimalarial activity of new atovaquone derivatives.” European Journal of Medicinal Chemistry, vol. 44, no. 11, Nov. 2009, pp. 4778-4782. https://doi.org/10.1016/j.ejmech.2009.07.021.