A review on recent developments of indole-containing antiviral agents
Publication type: Journal Article
Publication date: 2015-01-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
25462257
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
Indole represents one of the most important privileged scaffolds in drug discovery. Indole derivatives have the unique property of mimicking the structure of peptides and to bind reversibly to enzymes, which provide tremendous opportunities to discover novel drugs with different modes of action. There are seven indole-containing commercial drugs in the Top-200 Best Selling Drugs by US Retail Sales in 2012. There are also an amazing number of approved indole-containing drugs in the market as well as compounds currently going through different clinical phases or registration statuses. This review focused on the recent development of indole derivatives as antiviral agents with the following objectives: 1) To present one of the most comprehensive listings of indole antiviral agents, drugs on market or compounds in clinical trials; 2) To focus on recent developments of indole compounds (including natural products) and their antiviral activities, summarize the structure property, hoping to inspire new and even more creative approaches; 3) To offer perspectives on how indole scaffolds as a privileged structure might be exploited in the future.
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806
Total citations:
806
Citations from 2025:
97
(12.04%)
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GOST
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Zhang M., Chen Q., Yang G. A review on recent developments of indole-containing antiviral agents // European Journal of Medicinal Chemistry. 2015. Vol. 89. pp. 421-441.
GOST all authors (up to 50)
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Zhang M., Chen Q., Yang G. A review on recent developments of indole-containing antiviral agents // European Journal of Medicinal Chemistry. 2015. Vol. 89. pp. 421-441.
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TY - JOUR
DO - 10.1016/j.ejmech.2014.10.065
UR - https://doi.org/10.1016/j.ejmech.2014.10.065
TI - A review on recent developments of indole-containing antiviral agents
T2 - European Journal of Medicinal Chemistry
AU - Zhang, Ming-Zhi
AU - Chen, Qiong
AU - Yang, Guangfu
PY - 2015
DA - 2015/01/01
PB - Elsevier
SP - 421-441
VL - 89
PMID - 25462257
SN - 0223-5234
SN - 1768-3254
ER -
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@article{2015_Zhang,
author = {Ming-Zhi Zhang and Qiong Chen and Guangfu Yang},
title = {A review on recent developments of indole-containing antiviral agents},
journal = {European Journal of Medicinal Chemistry},
year = {2015},
volume = {89},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.ejmech.2014.10.065},
pages = {421--441},
doi = {10.1016/j.ejmech.2014.10.065}
}