Structural isomers of cinnamic hydroxamic acids block HCV replication via different mechanisms
Publication type: Journal Article
Publication date: 2019-12-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
31557613
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
A set of ortho- , meta- and para- substituted cinnamic hydroxamic acids (CHAs) was synthesized. In each series of structural isomers, a phenyl substituent was linked to an aromatic ring of the parent cinnamic acid via a linker of one to four atoms in length. Using a cell test system with the full-length replicon of hepatitis C virus (HCV), we established a relationship between the suppression of HCV replicon propagation and the inhibition of class I/IIb histone deacetylases (HDACs). Anti-HCV activity correlated with the inhibition of HDAC8 in the case of ortho- CHAs, while in the case of meta- CHAs it correlated with the inhibition of HDAC1/2/3 and HDAC6. The antiviral activity of para- CHAs was many times stronger than that of meta- CHAs with about the same efficiency of HDAC1/2/3/6 inhibition, which indicated the existence of an additional cell target that does not belong to the studied group of HDACs.
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9
Total citations:
9
Citations from 2024:
3
(33%)
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GOST
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Kozlov M. V. et al. Structural isomers of cinnamic hydroxamic acids block HCV replication via different mechanisms // European Journal of Medicinal Chemistry. 2019. Vol. 183. p. 111723.
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Kozlov M. V., Konduktorov K. A., Malikova A. Z., Kamarova K. A., Shcherbakova A. S., Solyev P. N., Кочетков С. Н. Structural isomers of cinnamic hydroxamic acids block HCV replication via different mechanisms // European Journal of Medicinal Chemistry. 2019. Vol. 183. p. 111723.
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RIS
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TY - JOUR
DO - 10.1016/j.ejmech.2019.111723
UR - https://doi.org/10.1016/j.ejmech.2019.111723
TI - Structural isomers of cinnamic hydroxamic acids block HCV replication via different mechanisms
T2 - European Journal of Medicinal Chemistry
AU - Kozlov, Maxim V
AU - Konduktorov, Konstantin A
AU - Malikova, Alsu Z
AU - Kamarova, Kamila A.
AU - Shcherbakova, Anastasia S
AU - Solyev, Pavel N.
AU - Кочетков, С. Н.
PY - 2019
DA - 2019/12/01
PB - Elsevier
SP - 111723
VL - 183
PMID - 31557613
SN - 0223-5234
SN - 1768-3254
ER -
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BibTex (up to 50 authors)
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@article{2019_Kozlov,
author = {Maxim V Kozlov and Konstantin A Konduktorov and Alsu Z Malikova and Kamila A. Kamarova and Anastasia S Shcherbakova and Pavel N. Solyev and С. Н. Кочетков},
title = {Structural isomers of cinnamic hydroxamic acids block HCV replication via different mechanisms},
journal = {European Journal of Medicinal Chemistry},
year = {2019},
volume = {183},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.ejmech.2019.111723},
pages = {111723},
doi = {10.1016/j.ejmech.2019.111723}
}
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