Molecules with versatile biological activities bearing antipyrinyl nucleus as pharmacophore
Jyotirmaya Sahoo
1
,
Chita Ranjan Sahoo
2
,
Priyambada Kshiroda Nandini Sarangi
3
,
Shakti Ketan Prusty
4
,
Rabindra N Padhy
5
,
Sudhir K Paidesetty
6
3
Department of Pharmaceutical Chemistry, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, 752101, Odisha, India
|
Publication type: Journal Article
Publication date: 2020-01-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
31791644
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
Antipyrine (1,2-dihydro-1,5-dimethyl-2-phenylpyrazole-3-one) in a structural frame consists of a five membered lactam pyrazolone heterocyclic ring as a pharmacophore moiety. It is evident from literature that the molecules having nitrogen bearing heterocyclic nuclei clearly exhibit several biological actions. Commercially available pyrazolone derivatives as drugs, analgin and metamizol are an established chemical class of analgesics. Recent trends of synthetic routes and several biological actions of antipyrine analogues are considered in this review. Indeed, the synthesized derivatives possess antipyrine moiety having versatile biological properties, antimicrobial, antitubercular, anthelmintic, antioxidant, analgesic, anti-inflammatory, cytotoxic and antiviral activities.
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30
Total citations:
30
Citations from 2025:
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(20%)
Cite this
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RIS |
BibTex
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GOST
Copy
Sahoo J. et al. Molecules with versatile biological activities bearing antipyrinyl nucleus as pharmacophore // European Journal of Medicinal Chemistry. 2020. Vol. 186. p. 111911.
GOST all authors (up to 50)
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Sahoo J., Sahoo C. R., Nandini Sarangi P. K., Prusty S. K., Padhy R. N., Paidesetty S. K. Molecules with versatile biological activities bearing antipyrinyl nucleus as pharmacophore // European Journal of Medicinal Chemistry. 2020. Vol. 186. p. 111911.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ejmech.2019.111911
UR - https://doi.org/10.1016/j.ejmech.2019.111911
TI - Molecules with versatile biological activities bearing antipyrinyl nucleus as pharmacophore
T2 - European Journal of Medicinal Chemistry
AU - Sahoo, Jyotirmaya
AU - Sahoo, Chita Ranjan
AU - Nandini Sarangi, Priyambada Kshiroda
AU - Prusty, Shakti Ketan
AU - Padhy, Rabindra N
AU - Paidesetty, Sudhir K
PY - 2020
DA - 2020/01/01
PB - Elsevier
SP - 111911
VL - 186
PMID - 31791644
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Sahoo,
author = {Jyotirmaya Sahoo and Chita Ranjan Sahoo and Priyambada Kshiroda Nandini Sarangi and Shakti Ketan Prusty and Rabindra N Padhy and Sudhir K Paidesetty},
title = {Molecules with versatile biological activities bearing antipyrinyl nucleus as pharmacophore},
journal = {European Journal of Medicinal Chemistry},
year = {2020},
volume = {186},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.ejmech.2019.111911},
pages = {111911},
doi = {10.1016/j.ejmech.2019.111911}
}