European Journal of Medicinal Chemistry, volume 225, pages 113752
PSMA-targeted low-molecular double conjugates for diagnostics and therapy
Publication type: Journal Article
Publication date: 2021-12-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.7
ISSN: 02235234, 17683254
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
This review presents data on dual conjugates of therapeutic and diagnostic action for targeted delivery to prostate cancer cells. The works of the last ten years on this topic were analyzed. The mail attention focuses on low-molecular-weight conjugates directed to the prostate-specific membrane antigen (PSMA); the comparison of high and low molecular weight PSMA-targeted conjugates was made. The considered conjugates were divided in the review into two main classes: diagnostic bimodal conjugates (which are containing two fragments for different types of diagnostics), theranostic conjugates (containing both therapeutic and diagnostic agents); also bimodal high molecular weight therapeutic conjugates containing two therapeutic agents are briefly discussed. The data of in vitro and in vivo studies for PSMA-targeted double conjugates available by the beginning of 2021 have been analyzed.
Citations by journals
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
3 publications, 37.5%
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Molecules
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Molecules
2 publications, 25%
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Expert Opinion on Drug Delivery
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Expert Opinion on Drug Delivery
1 publication, 12.5%
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European Journal of Medicinal Chemistry
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European Journal of Medicinal Chemistry
1 publication, 12.5%
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
5 publications, 62.5%
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Taylor & Francis
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Taylor & Francis
1 publication, 12.5%
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Elsevier
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Elsevier
1 publication, 12.5%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Petrov S. B. et al. PSMA-targeted low-molecular double conjugates for diagnostics and therapy // European Journal of Medicinal Chemistry. 2021. Vol. 225. p. 113752.
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Petrov S. B., Zyk N. Y., Machulkin A. E., Beloglazkina E. K., Majouga A. G. PSMA-targeted low-molecular double conjugates for diagnostics and therapy // European Journal of Medicinal Chemistry. 2021. Vol. 225. p. 113752.
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TY - JOUR
DO - 10.1016/j.ejmech.2021.113752
UR - https://doi.org/10.1016%2Fj.ejmech.2021.113752
TI - PSMA-targeted low-molecular double conjugates for diagnostics and therapy
T2 - European Journal of Medicinal Chemistry
AU - Petrov, Stanislav B.
AU - Zyk, Nikolay Y
AU - Machulkin, Aleksei E.
AU - Beloglazkina, Elena K.
AU - Majouga, Alexander G.
PY - 2021
DA - 2021/12/01 00:00:00
PB - Elsevier
SP - 113752
VL - 225
SN - 0223-5234
SN - 1768-3254
ER -
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@article{2021_Petrov,
author = {Stanislav B. Petrov and Nikolay Y Zyk and Aleksei E. Machulkin and Elena K. Beloglazkina and Alexander G. Majouga},
title = {PSMA-targeted low-molecular double conjugates for diagnostics and therapy},
journal = {European Journal of Medicinal Chemistry},
year = {2021},
volume = {225},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.ejmech.2021.113752},
pages = {113752},
doi = {10.1016/j.ejmech.2021.113752}
}