Open Access
FEBS Letters, volume 579, issue 25, pages 5439-5442
How can elongation factors EF-G and EF-Tu discriminate the functional state of the ribosome using the same binding site?
Publication type: Journal Article
Publication date: 2005-09-26
Journal:
FEBS Letters
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.5
ISSN: 00145793, 18733468
Biochemistry
Molecular Biology
Cell Biology
Genetics
Structural Biology
Biophysics
Abstract
Elongation factors EF‐G and EF‐Tu are structural homologues and share near‐identical binding sites on the ribosome, which encompass the GTPase‐associated centre (GAC) and the sarcin‐ricin loop (SRL). The SRL is fixed structure in the ribosome and contacts elongation factors in the vicinity of their GTP‐binding site. In contrast, the GAC is mobile and we hypothesize that it interacts with the alpha helix D of the EF‐Tu G‐domain in the same way as with the alpha helix A of the G′‐domain of EF‐G. The mutual locations of these helices and GTP‐binding sites in the structures of EF‐Tu and EF‐G are different. Thus, the orientation of the GAC relative to the SRL determines whether EF‐G or EF‐Tu will bind to the ribosome.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Sergiev P. V., Bogdanov A. A., Dontsova O. A. How can elongation factors EF-G and EF-Tu discriminate the functional state of the ribosome using the same binding site? // FEBS Letters. 2005. Vol. 579. No. 25. pp. 5439-5442.
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Sergiev P. V., Bogdanov A. A., Dontsova O. A. How can elongation factors EF-G and EF-Tu discriminate the functional state of the ribosome using the same binding site? // FEBS Letters. 2005. Vol. 579. No. 25. pp. 5439-5442.
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TY - JOUR
DO - 10.1016/j.febslet.2005.09.010
UR - https://doi.org/10.1016%2Fj.febslet.2005.09.010
TI - How can elongation factors EF-G and EF-Tu discriminate the functional state of the ribosome using the same binding site?
T2 - FEBS Letters
AU - Dontsova, Olga A.
AU - Sergiev, Petr V.
AU - Bogdanov, Alexey A.
PY - 2005
DA - 2005/09/26 00:00:00
PB - Wiley
SP - 5439-5442
IS - 25
VL - 579
SN - 0014-5793
SN - 1873-3468
ER -
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@article{2005_Sergiev,
author = {Olga A. Dontsova and Petr V. Sergiev and Alexey A. Bogdanov},
title = {How can elongation factors EF-G and EF-Tu discriminate the functional state of the ribosome using the same binding site?},
journal = {FEBS Letters},
year = {2005},
volume = {579},
publisher = {Wiley},
month = {sep},
url = {https://doi.org/10.1016%2Fj.febslet.2005.09.010},
number = {25},
pages = {5439--5442},
doi = {10.1016/j.febslet.2005.09.010}
}
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MLA
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Sergiev, Petr V., et al. “How can elongation factors EF-G and EF-Tu discriminate the functional state of the ribosome using the same binding site?.” FEBS Letters, vol. 579, no. 25, Sep. 2005, pp. 5439-5442. https://doi.org/10.1016%2Fj.febslet.2005.09.010.
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