Free Radical Biology and Medicine, volume 143, pages 522-533
High-effective reactive oxygen species inducer based on Mn-tetraphenylporphyrin loaded PLGA nanoparticles in binary catalyst therapy
Faustova Maria
1
,
Sokol Maria
2
,
Nikolskaya Elena
3
,
Fomicheva Margarita
2
,
Yabbarov Nikita
,
Zabolotsky Artur
4
,
Mollaev Murad
,
Zhunina Olga
3
,
Lobanov Anton
,
Severin Evgeniy
2
,
Mollaev Murad D
1
,
Shchegolikhin A. N.
3
,
2
JSC Russian Research Center for Molecular Diagnostics and Therapy, 117149, Moscow, Russia.
|
Publication type: Journal Article
Publication date: 2019-11-01
Journal:
Free Radical Biology and Medicine
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.4
ISSN: 08915849, 18734596
Biochemistry
Physiology (medical)
Abstract
The mechanisms of binary catalyst therapy (BCT) and photodynamic therapy (PDT) are based on the formation of reactive oxygen species (ROS). This ROS formation results from specific chemical reactions. In BCT, light exposure does not necessarily initiate ROS formation and BCT application is not limited to regions of tissues that are accessible to illumination like photodynamic therapy (PDT). The principle of BCT is electron transition, resulting in the interaction of a transition metal complex (catalyst) and substrate molecule. MnIII- tetraphenylporphyrin chloride (MnClTPP) in combination with an ascorbic acid (AA) has been proposed as an appropriate candidate for cancer treatment regarding the active agents in BCT. The goal of this study was to determine whether MnClTPP in combination with AA would be a promising agent for BCT. The problem of used MnClTPP's, low solubility in water, was solved by MnClTPP loading into PLGA matrix. H2O2 produced during AA decomposition oxidized MnClTPP to high-reactive oxo-MnV species. MnClTPP in presence AA leads to the production of excessive ROS levels in vitro. ROS are mainly substrates of catalase and superoxide dismutase (H2O2 and O2●-). SOD1 and catalase were identified as the key players of the MnClTPP ROS-induced cell defense system. The cytotoxicity of MnClTPP-loaded nanoparticles (NPs) was greatly increased in the presence of specific catalase inhibitor (3-amino-1,2,4-triazole (3AT)) and superoxide dismutase 1 (SOD1) inhibitor (diethyldithiocarbamate (DDC)). Cell death resulted from the combined activation of caspase-dependent (caspase 3/9 system) and independent pathways, namely the AIF translocation to nuclei. Preliminary acute toxicity and in vivo anticancer studies have been revealed the safe and potent anticancer effect of PLGA-entrapped MnClTPP in combination with AA. The findings indicate that MnClTPP-loaded PLGA NPs are promising agents for BCT.
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Faustova M. et al. High-effective reactive oxygen species inducer based on Mn-tetraphenylporphyrin loaded PLGA nanoparticles in binary catalyst therapy // Free Radical Biology and Medicine. 2019. Vol. 143. pp. 522-533.
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Faustova M., Nikolskaya E., Sokol M., Zabolotsky A., Mollaev M., Zhunina O., Fomicheva M., Lobanov A., Severin E., Yabbarov N., Mollaev M. D., Shchegolikhin A. N., Yabbarov N. G. High-effective reactive oxygen species inducer based on Mn-tetraphenylporphyrin loaded PLGA nanoparticles in binary catalyst therapy // Free Radical Biology and Medicine. 2019. Vol. 143. pp. 522-533.
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TY - JOUR
DO - 10.1016/j.freeradbiomed.2019.09.008
UR - https://doi.org/10.1016%2Fj.freeradbiomed.2019.09.008
TI - High-effective reactive oxygen species inducer based on Mn-tetraphenylporphyrin loaded PLGA nanoparticles in binary catalyst therapy
T2 - Free Radical Biology and Medicine
AU - Faustova, Maria
AU - Nikolskaya, Elena
AU - Sokol, Maria
AU - Zabolotsky, Artur
AU - Mollaev, Murad
AU - Zhunina, Olga
AU - Fomicheva, Margarita
AU - Lobanov, Anton
AU - Severin, Evgeniy
AU - Yabbarov, Nikita
AU - Mollaev, Murad D
AU - Shchegolikhin, A. N.
AU - Yabbarov, Nikita G
PY - 2019
DA - 2019/11/01 00:00:00
PB - Elsevier
SP - 522-533
VL - 143
SN - 0891-5849
SN - 1873-4596
ER -
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@article{2019_Faustova,
author = {Maria Faustova and Elena Nikolskaya and Maria Sokol and Artur Zabolotsky and Murad Mollaev and Olga Zhunina and Margarita Fomicheva and Anton Lobanov and Evgeniy Severin and Nikita Yabbarov and Murad D Mollaev and A. N. Shchegolikhin and Nikita G Yabbarov},
title = {High-effective reactive oxygen species inducer based on Mn-tetraphenylporphyrin loaded PLGA nanoparticles in binary catalyst therapy},
journal = {Free Radical Biology and Medicine},
year = {2019},
volume = {143},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016%2Fj.freeradbiomed.2019.09.008},
pages = {522--533},
doi = {10.1016/j.freeradbiomed.2019.09.008}
}