Open Access
Hydrolysis and enzymatic degradation of Novichok nerve agents
Тип публикации: Journal Article
Дата публикации: 2020-01-07
PubMed ID:
32042950
Multidisciplinary
Краткое описание
Several parameters of the Novichok nerve agents A230, A232 and A234 were determined. Hydrolysis rates were approximately one to three orders of magnitude slower than G-type nerve agents and approximately zero to two orders of magnitude slower than V-type nerve agents. A230 was the most labile Novichok compound followed by A232 then A234. Activation energies (Ea) and frequency factors (A) were determined for all three compounds. The organophosphorus acid anhydrolase (OPAA) enzyme had catalytic efficiencies on the Novichok compounds ranging between 104 and 105 M-1 min-1 with the highest kcat/Km value for A230, then A232 and lastly, A234.
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ГОСТ
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Harvey S., Mcmahon L. R., Berg F. J. Hydrolysis and enzymatic degradation of Novichok nerve agents // Heliyon. 2020. Vol. 6. No. 1. p. e03153.
ГОСТ со всеми авторами (до 50)
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Harvey S., Mcmahon L. R., Berg F. J. Hydrolysis and enzymatic degradation of Novichok nerve agents // Heliyon. 2020. Vol. 6. No. 1. p. e03153.
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TY - JOUR
DO - 10.1016/j.heliyon.2019.e03153
UR - https://doi.org/10.1016/j.heliyon.2019.e03153
TI - Hydrolysis and enzymatic degradation of Novichok nerve agents
T2 - Heliyon
AU - Harvey, Steven
AU - Mcmahon, Leslie R
AU - Berg, Frederic J
PY - 2020
DA - 2020/01/07
PB - Elsevier
SP - e03153
IS - 1
VL - 6
PMID - 32042950
SN - 2405-8440
ER -
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BibTex (до 50 авторов)
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@article{2020_Harvey,
author = {Steven Harvey and Leslie R Mcmahon and Frederic J Berg},
title = {Hydrolysis and enzymatic degradation of Novichok nerve agents},
journal = {Heliyon},
year = {2020},
volume = {6},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.heliyon.2019.e03153},
number = {1},
pages = {e03153},
doi = {10.1016/j.heliyon.2019.e03153}
}
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MLA
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Harvey, Steven, et al. “Hydrolysis and enzymatic degradation of Novichok nerve agents.” Heliyon, vol. 6, no. 1, Jan. 2020, p. e03153. https://doi.org/10.1016/j.heliyon.2019.e03153.