Open Access
Hydrolysis and enzymatic degradation of Novichok nerve agents
Publication type: Journal Article
Publication date: 2020-01-07
PubMed ID:
32042950
Multidisciplinary
Abstract
Several parameters of the Novichok nerve agents A230, A232 and A234 were determined. Hydrolysis rates were approximately one to three orders of magnitude slower than G-type nerve agents and approximately zero to two orders of magnitude slower than V-type nerve agents. A230 was the most labile Novichok compound followed by A232 then A234. Activation energies (Ea) and frequency factors (A) were determined for all three compounds. The organophosphorus acid anhydrolase (OPAA) enzyme had catalytic efficiencies on the Novichok compounds ranging between 104 and 105 M-1 min-1 with the highest kcat/Km value for A230, then A232 and lastly, A234.
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70
Total citations:
70
Citations from 2024:
28
(40%)
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GOST
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Harvey S., Mcmahon L. R., Berg F. J. Hydrolysis and enzymatic degradation of Novichok nerve agents // Heliyon. 2020. Vol. 6. No. 1. p. e03153.
GOST all authors (up to 50)
Copy
Harvey S., Mcmahon L. R., Berg F. J. Hydrolysis and enzymatic degradation of Novichok nerve agents // Heliyon. 2020. Vol. 6. No. 1. p. e03153.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.heliyon.2019.e03153
UR - https://doi.org/10.1016/j.heliyon.2019.e03153
TI - Hydrolysis and enzymatic degradation of Novichok nerve agents
T2 - Heliyon
AU - Harvey, Steven
AU - Mcmahon, Leslie R
AU - Berg, Frederic J
PY - 2020
DA - 2020/01/07
PB - Elsevier
SP - e03153
IS - 1
VL - 6
PMID - 32042950
SN - 2405-8440
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Harvey,
author = {Steven Harvey and Leslie R Mcmahon and Frederic J Berg},
title = {Hydrolysis and enzymatic degradation of Novichok nerve agents},
journal = {Heliyon},
year = {2020},
volume = {6},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.heliyon.2019.e03153},
number = {1},
pages = {e03153},
doi = {10.1016/j.heliyon.2019.e03153}
}
Cite this
MLA
Copy
Harvey, Steven, et al. “Hydrolysis and enzymatic degradation of Novichok nerve agents.” Heliyon, vol. 6, no. 1, Jan. 2020, p. e03153. https://doi.org/10.1016/j.heliyon.2019.e03153.