Open Access

International Journal of Pharmaceutics

, volume 601 , pages 120600

Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for the treatment of anosmia in COVID-19 patients: Design, in-vitro characterization and clinical evaluation

Soad A Mohamad ¹

AHMED M. BADAWI ²

Heba Mansour ³

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Deraya University, Minia, Egypt |

Department of Otorhinolaryngology, Faculty of Medicine, Minia University, Minia, Egypt, |

Department of Pharmaceutics, Faculty of Pharmacy Minia University Minia Egypt |

Publication type: Journal Article

Publication date: 2021-05-01

Elsevier

International Journal of Pharmaceutics

scimago Q1

wos Q1

SJR: 0.988

CiteScore: 10.1

Impact factor: 5.2

ISSN: 03785173, 18733476

DOI: 10.1016/j.ijpharm.2021.120600

Copy DOI

PubMed ID: 33862126

Pharmaceutical Science

Abstract

The present work aimed to formulate intranasal insulin fast-dissolving films for treatment of anosmia in patients post COVID-19 infection. Variant films were prepared employing the casting method and using hydroxypropyl methyl cellulose and polyvinyl alcohol. The formulated films were investigated for insulin content, weight variation, surface pH, thickness, folding endurance and disintegration time. In vitro release study was conducted for the selected formulations (F6, F7, F8). A drug/polymer interaction was investigated in the optimized formulation (F7) employing Fourier transform infrared spectroscopy. Clinical study was accomplished for F7 on 20 patients. Sniffin’s and olfactory discrimination tests were used for assessing patients. The formulated films displayed appropriate physical characteristics. F7 showed the shortest disintegration time (50 ± 7 s) and fastest release. It displayed compatibility between the drug and the used polymers. The results of the clinical study revealed a significant increase in the olfactory detection scores and olfactory discrimination values in the intervention group (7.9 ± 1.2, 6.7 ± 0.5 respectively) compared to placebo group (3 ± 0.8, 2.8 ± 1).. Intervention group showed significant differences between these scores before and after treatment while the placebo group did not display any significant differences. Thus, the optimized film can be considered as an auspicious approach for managing post COVID-19 anosmia.

Found

1 citation

Gaynanova Gulnara

PhD in Chemistry

74 publications, 1 073 citations, 1 review

h-index: 18

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Colloidal chemistry

Drug delivery systems

Physical Chemistry

Supramolecular chemistry

Surfactants

1 citation

Vasilyeva Leysan

PhD in Chemistry

29 publications, 492 citations

h-index: 14

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Colloidal chemistry

Drug delivery systems

Physical Chemistry

Surfactants

1 citation

Zakharova Lucia

DSc in Chemistry, professor

394 publications, 6 176 citations

h-index: 36

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

1 citation

Moschopoulos Charalampos

33 publications, 594 citations, 47 reviews

h-index: 12

National and Kapodistrian University of Athens

Research interests

Antimicrobial resistance

1 citation

Wildi Karin

50 publications, 636 citations

h-index: 14

University of Basel

University of Queensland

University Hospital of Basel

Prince Charles Hospital

Research interests

ARDS

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Mohamad S. A., BADAWI A. M., Mansour H. Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for the treatment of anosmia in COVID-19 patients: Design, in-vitro characterization and clinical evaluation // International Journal of Pharmaceutics. 2021. Vol. 601. p. 120600.

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RIS Copy

TY - JOUR

DO - 10.1016/j.ijpharm.2021.120600

UR - https://doi.org/10.1016/j.ijpharm.2021.120600

TI - Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for the treatment of anosmia in COVID-19 patients: Design, in-vitro characterization and clinical evaluation

T2 - International Journal of Pharmaceutics

AU - Mohamad, Soad A

AU - BADAWI, AHMED M.

AU - Mansour, Heba

PY - 2021

DA - 2021/05/01

PB - Elsevier

SP - 120600

VL - 601

PMID - 33862126

SN - 0378-5173

SN - 1873-3476

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Mohamad,

author = {Soad A Mohamad and AHMED M. BADAWI and Heba Mansour},

title = {Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for the treatment of anosmia in COVID-19 patients: Design, in-vitro characterization and clinical evaluation},

journal = {International Journal of Pharmaceutics},

year = {2021},

volume = {601},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016/j.ijpharm.2021.120600},

pages = {120600},

doi = {10.1016/j.ijpharm.2021.120600}

}

Publisher

Elsevier

Journal

International Journal of Pharmaceutics

scimago Q1

wos Q1

SJR

0.988

CiteScore

10.1

Impact factor

5.2

ISSN

03785173 (Print)

18733476 (Electronic)