Journal of Controlled Release, volume 162, issue 3, pages 599-605

Controlled enzyme-catalyzed degradation of polymeric capsules templated on CaCO₃: influence of the number of LbL layers, conditions of degradation, and disassembly of multicompartments.

Borodina Tatiana
Yashchenok Alexey
Konrad Manfred
Skirtach Andre
Möhwald Helmuth
Borodina Tatiana 3
Konrad Manfred 4
Möhwald Helmuth 2
2
 
Helmuth Möhwald, Grenzflächen, Max Planck Institute of Colloids and Interfaces, Max Planck Society
3
 
Grenzflächen, Max Planck Institute of Colloids and Interfaces, Max Planck Society
4
 
Research Group of Enzyme Biochemistry, MPI for Biophysical Chemistry, Max Planck Society
Publication typeJournal Article
Publication date2012-09-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor10.8
ISSN01683659, 18734995
Pharmaceutical Science
Abstract
Enzyme-catalyzed degradation of CaCO₃-templated capsules is presented. We investigate a) biodegradable, b) mixed biodegradable/synthetic, and c) multicompartment polyelectrolyte multilayer capsules with different numbers of polymer layers. Using confocal laser scanning microscopy we observed the kinetics of the non-specific protease Pronase-induced degradation of capsules is slowed down on the order of hours by either increasing the number of layers in the wall of biodegradable capsules, or by inserting synthetic polyelectrolyte multilayers into the shell comprised of biodegradable polymers. The degradation rate increases with the concentration of Pronase. Controlled detachment of subcompartments of multicompartment capsules, with potential for intracellular delivery or in-vivo applications, is also shown.

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Marchenko I. et al. Controlled enzyme-catalyzed degradation of polymeric capsules templated on CaCO₃: influence of the number of LbL layers, conditions of degradation, and disassembly of multicompartments. // Journal of Controlled Release. 2012. Vol. 162. No. 3. pp. 599-605.
GOST all authors (up to 50) Copy
Marchenko I., Yashchenok A., Borodina T., Konrad M., Skirtach A., Bukreeva T., Möhwald H., Yashchenok A. M., Borodina T., Konrad M., Möhwald H., Skirtach A. Controlled enzyme-catalyzed degradation of polymeric capsules templated on CaCO₃: influence of the number of LbL layers, conditions of degradation, and disassembly of multicompartments. // Journal of Controlled Release. 2012. Vol. 162. No. 3. pp. 599-605.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.jconrel.2012.08.006
UR - https://doi.org/10.1016%2Fj.jconrel.2012.08.006
TI - Controlled enzyme-catalyzed degradation of polymeric capsules templated on CaCO₃: influence of the number of LbL layers, conditions of degradation, and disassembly of multicompartments.
T2 - Journal of Controlled Release
AU - Marchenko, Irina
AU - Yashchenok, Alexey
AU - Borodina, Tatiana
AU - Konrad, Manfred
AU - Skirtach, Andre
AU - Bukreeva, Tatiana
AU - Möhwald, Helmuth
AU - Yashchenok, Alexey M
AU - Borodina, Tatiana
AU - Konrad, Manfred
AU - Möhwald, Helmuth
AU - Skirtach, Andre G.
PY - 2012
DA - 2012/09/01 00:00:00
PB - Elsevier
SP - 599-605
IS - 3
VL - 162
SN - 0168-3659
SN - 1873-4995
ER -
BibTex |
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BibTex Copy
@article{2012_Marchenko,
author = {Irina Marchenko and Alexey Yashchenok and Tatiana Borodina and Manfred Konrad and Andre Skirtach and Tatiana Bukreeva and Helmuth Möhwald and Alexey M Yashchenok and Tatiana Borodina and Manfred Konrad and Helmuth Möhwald and Andre G. Skirtach},
title = {Controlled enzyme-catalyzed degradation of polymeric capsules templated on CaCO₃: influence of the number of LbL layers, conditions of degradation, and disassembly of multicompartments.},
journal = {Journal of Controlled Release},
year = {2012},
volume = {162},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2Fj.jconrel.2012.08.006},
number = {3},
pages = {599--605},
doi = {10.1016/j.jconrel.2012.08.006}
}
MLA
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MLA Copy
Marchenko, Irina, et al. “Controlled enzyme-catalyzed degradation of polymeric capsules templated on CaCO₃: influence of the number of LbL layers, conditions of degradation, and disassembly of multicompartments..” Journal of Controlled Release, vol. 162, no. 3, Sep. 2012, pp. 599-605. https://doi.org/10.1016%2Fj.jconrel.2012.08.006.
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