Transdermal delivery of insulin across human skin in vitro with 3D printed hollow microneedles
Iakovos Xenikakis
1
,
Konstantinos Tsongas
2
,
Emmanouil K Tzimtzimis
2
,
Orestis L Katsamenis
3
,
Efterpi Demiri
4
,
Constantinos K Zacharis
5
,
Despoina Georgiou
6
,
Eleni Kalogianni
6
,
DIMITRIOS G. FATOUROS
1
2
Тип публикации: Journal Article
Дата публикации: 2022-01-01
scimago Q1
wos Q1
БС1
SJR: 0.817
CiteScore: 8.3
Impact factor: 4.9
ISSN: 17732247, 25888943, 11571489
Pharmaceutical Science
Краткое описание
In the current study hollow microneedles (HMNs) were fabricated by means of vat polymerization method for the transdermal delivery of insulin. Two geometries of HMNs were designed in a Computer Aided Design (CAD) software namely, curved pyramid and syringe-like and fabricated with Liquid Crystal Display (LCD) method. Dimensions were determined and quality features were imaged with scanning electron microscopy (SEM). Volumetric characterization of HMNs and microchannels was performed by microfocus computed tomography (μCT) whereas mechanical characterization and skin penetration tests of the two geometries were carried out both experimentally and by Finite Element Analysis (FEA) simulation. Diffusion studies of insulin across full thickness human skin were performed in vitro using Franz diffusion cells. Insulin samples were analyzed with liquid chromatography-mass spectrometry (LC-MS). The results show that the transport might be affected by the shape of the microneedles.
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Xenikakis I. et al. Transdermal delivery of insulin across human skin in vitro with 3D printed hollow microneedles // Journal of Drug Delivery Science and Technology. 2022. Vol. 67. p. 102891.
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Xenikakis I., Tsongas K., Tzimtzimis E. K., Katsamenis O. L., Demiri E., Zacharis C. K., Georgiou D., Kalogianni E., Tzetzis D., FATOUROS D. G. Transdermal delivery of insulin across human skin in vitro with 3D printed hollow microneedles // Journal of Drug Delivery Science and Technology. 2022. Vol. 67. p. 102891.
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TY - JOUR
DO - 10.1016/j.jddst.2021.102891
UR - https://doi.org/10.1016/j.jddst.2021.102891
TI - Transdermal delivery of insulin across human skin in vitro with 3D printed hollow microneedles
T2 - Journal of Drug Delivery Science and Technology
AU - Xenikakis, Iakovos
AU - Tsongas, Konstantinos
AU - Tzimtzimis, Emmanouil K
AU - Katsamenis, Orestis L
AU - Demiri, Efterpi
AU - Zacharis, Constantinos K
AU - Georgiou, Despoina
AU - Kalogianni, Eleni
AU - Tzetzis, Dimitrios
AU - FATOUROS, DIMITRIOS G.
PY - 2022
DA - 2022/01/01
PB - Elsevier
SP - 102891
VL - 67
SN - 1773-2247
SN - 2588-8943
SN - 1157-1489
ER -
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@article{2022_Xenikakis,
author = {Iakovos Xenikakis and Konstantinos Tsongas and Emmanouil K Tzimtzimis and Orestis L Katsamenis and Efterpi Demiri and Constantinos K Zacharis and Despoina Georgiou and Eleni Kalogianni and Dimitrios Tzetzis and DIMITRIOS G. FATOUROS},
title = {Transdermal delivery of insulin across human skin in vitro with 3D printed hollow microneedles},
journal = {Journal of Drug Delivery Science and Technology},
year = {2022},
volume = {67},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.jddst.2021.102891},
pages = {102891},
doi = {10.1016/j.jddst.2021.102891}
}
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