Journal of Fluorine Chemistry, volume 131, issue 11, pages 1071-1081
Fluorine in health care: Organofluorine containing blockbuster drugs
Publication type: Journal Article
Publication date: 2010-11-01
Journal:
Journal of Fluorine Chemistry
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 1.9
ISSN: 00221139
Organic Chemistry
Biochemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Environmental Chemistry
Abstract
Organic fluorine compounds have had a profound impact on the development of bioactives for the modern pharmaceuticals market. It is estimated that up to 20% of pharmaceuticals prescribed or administered in the clinic contain a fluorine atom and 30% of the leading 30 blockbuster drugs by sales contain a fluorine. In this Highlight review, the top 10 fluorine containing pharmaceuticals (by US Sales in 2008) are highlighted. By this measure, these are currently the most significant fluorinated compounds impacting on health care. They embrace statins (Lipitor, Crestor, Vytorin, Zetia/Ezetimibe), anti-inflammatories (fluticasone propionate, Celebrex), antacids (Prevacid), antidepressants (Lexapro), neuroleptics (Risperdal) and antibiotics (Levaquin). In each case the structures and modes of action of these important drugs compounds are reviewed and representative synthetic routes are highlighted.
Top-30
Citations by journals
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8 publications, 1.08%
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7 publications, 0.94%
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7 publications, 0.94%
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6 publications, 0.81%
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Mendeleev Communications
5 publications, 0.67%
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Citations by publishers
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Wiley
214 publications, 28.76%
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Elsevier
149 publications, 20.03%
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American Chemical Society (ACS)
147 publications, 19.76%
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Royal Society of Chemistry (RSC)
109 publications, 14.65%
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Springer Nature
28 publications, 3.76%
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Multidisciplinary Digital Publishing Institute (MDPI)
19 publications, 2.55%
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Beilstein-Institut
17 publications, 2.28%
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Thieme
15 publications, 2.02%
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Taylor & Francis
10 publications, 1.34%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
4 publications, 0.54%
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Bentham Science
4 publications, 0.54%
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Pleiades Publishing
4 publications, 0.54%
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The Electrochemical Society
2 publications, 0.27%
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Pharmaceutical Society of Japan
2 publications, 0.27%
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Frontiers Media S.A.
2 publications, 0.27%
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Walter de Gruyter
2 publications, 0.27%
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American Institute of Physics (AIP)
2 publications, 0.27%
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CSIRO Publishing
1 publication, 0.13%
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International Union of Crystallography (IUCr)
1 publication, 0.13%
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Society of Nuclear Medicine and Molecular Imaging
1 publication, 0.13%
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American Association for the Advancement of Science (AAAS)
1 publication, 0.13%
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Pesticide Science Society of Japan/Nippon Noyaku Gakkai
1 publication, 0.13%
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Hindawi Limited
1 publication, 0.13%
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OAE Publishing Inc.
1 publication, 0.13%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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O'Hagan D. Fluorine in health care: Organofluorine containing blockbuster drugs // Journal of Fluorine Chemistry. 2010. Vol. 131. No. 11. pp. 1071-1081.
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O'Hagan D. Fluorine in health care: Organofluorine containing blockbuster drugs // Journal of Fluorine Chemistry. 2010. Vol. 131. No. 11. pp. 1071-1081.
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TY - JOUR
DO - 10.1016/j.jfluchem.2010.03.003
UR - https://doi.org/10.1016/j.jfluchem.2010.03.003
TI - Fluorine in health care: Organofluorine containing blockbuster drugs
T2 - Journal of Fluorine Chemistry
AU - O'Hagan, David
PY - 2010
DA - 2010/11/01 00:00:00
PB - Elsevier
SP - 1071-1081
IS - 11
VL - 131
SN - 0022-1139
ER -
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@article{2010_O'Hagan,
author = {David O'Hagan},
title = {Fluorine in health care: Organofluorine containing blockbuster drugs},
journal = {Journal of Fluorine Chemistry},
year = {2010},
volume = {131},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.jfluchem.2010.03.003},
number = {11},
pages = {1071--1081},
doi = {10.1016/j.jfluchem.2010.03.003}
}
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O'Hagan, David. “Fluorine in health care: Organofluorine containing blockbuster drugs.” Journal of Fluorine Chemistry, vol. 131, no. 11, Nov. 2010, pp. 1071-1081. https://doi.org/10.1016/j.jfluchem.2010.03.003.