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Journal of Saudi Chemical Society

, том 18 , издание 6 , страницы 953-962

Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens

Тип публикации: Journal Article

Дата публикации: 2014-12-01

King Saud University

Journal of Saudi Chemical Society

scimago Q1

wos Q1

БС1

SJR: 0.939

CiteScore: 10

Impact factor: 5.8

ISSN: 13196103, 22124640

DOI: 10.1016/j.jscs.2011.11.020

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General Chemistry

Краткое описание

Copper based metallo drugs were prepared and their antibacterial, antifungal, molecular mechanism of [Cu(SAla)Phen]·H 2 O and [Cu(SAla)bpy]·H 2 O complexes were investigated. The [Cu(SAla)Phen]·H 2 O and [Cu(SAla)bpy]·H 2 O were derived from the Schiff base alanine salicylaldehyde. [Cu(SAla)Phen]·H 2 O showed noteworthy antibacterial and antifungal activity than the [Cu(SAla)bpy]·H 2 O and ligand alanine, salicylaldehyde. The [Cu(SAla)Phen]·H 2 O complex showed significant antibacterial activity against Salmonella typhi , Staphylococcus aureus , Salmonella paratyphi and the antifungal activity against Candida albicans and Cryptococcus neoformans in well diffusion assay. The mode of action of copper (II) complex was analyzed by DNA cleavage activity and in silico molecular docking. The present findings provide important insight into the molecular mechanism of copper (II) complexes in susceptible bacterial and fungal pathogens. These results collectively support the use of [Cu(SAla)Phen]·H 2 O complex as a suitable drug to treat bacterial and fungal infections.

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ГОСТ |

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Chandraleka S. et al. Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens // Journal of Saudi Chemical Society. 2014. Vol. 18. No. 6. pp. 953-962.

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Chandraleka S., Ramya K. K., Chandramohan G., Dhanasekaran D., Priyadharshini A., Panneerselvam A. Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens // Journal of Saudi Chemical Society. 2014. Vol. 18. No. 6. pp. 953-962.

RIS |

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TY - JOUR

DO - 10.1016/j.jscs.2011.11.020

UR - https://doi.org/10.1016/j.jscs.2011.11.020

TI - Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens

T2 - Journal of Saudi Chemical Society

AU - Chandraleka, S.

AU - Ramya K., K

AU - Chandramohan, G.

AU - Dhanasekaran, D.

AU - Priyadharshini, A.

AU - Panneerselvam, A

PY - 2014

DA - 2014/12/01

PB - King Saud University

SP - 953-962

IS - 6

VL - 18

SN - 1319-6103

SN - 2212-4640

ER -

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@article{2014_Chandraleka,

author = {S. Chandraleka and K Ramya K. and G. Chandramohan and D. Dhanasekaran and A. Priyadharshini and A Panneerselvam},

title = {Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens},

journal = {Journal of Saudi Chemical Society},

year = {2014},

volume = {18},

publisher = {King Saud University},

month = {dec},

url = {https://doi.org/10.1016/j.jscs.2011.11.020},

number = {6},

pages = {953--962},

doi = {10.1016/j.jscs.2011.11.020}

}

MLA

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MLA Скопировать

Chandraleka, S., et al. “Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens.” Journal of Saudi Chemical Society, vol. 18, no. 6, Dec. 2014, pp. 953-962. https://doi.org/10.1016/j.jscs.2011.11.020.

Издатель

King Saud University

Журнал

Journal of Saudi Chemical Society

scimago Q1

wos Q1

БС1

SJR

0.939

CiteScore

Impact factor

5.8

ISSN

13196103 (Print)

22124640