1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy
Igor V. Vystorop
1
,
Nina P Konovalova
1
,
Tatyana E. Sashenkova
1
,
Elena N Berseneva
1
,
A.V Chernyak
1
,
Boris S Fedorov
1
,
Remir G Kostyanovsky
2
Publication type: Journal Article
Publication date: 2011-09-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Condensation of glycine and dl-alanine hydroxamic acids with 1-methyl-4-piperidone regioselectively gave the corresponding titled spiro piperidine hydroxyimidazolidinones capable of enhancing sensitivity of P388 and L1210 leukemias in mice models to the known anticancer drugs cisplatin and cyclophosphamide.
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Vystorop I. V. et al. 1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy // Mendeleev Communications. 2011. Vol. 21. No. 5. pp. 239-241.
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Vystorop I. V., Konovalova N. P., Sashenkova T. E., Berseneva E. N., Chernyak A., Fedorov B. S., Kostyanovsky R. G. 1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy // Mendeleev Communications. 2011. Vol. 21. No. 5. pp. 239-241.
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TY - JOUR
DO - 10.1016/j.mencom.2011.09.002
UR - https://linkinghub.elsevier.com/retrieve/pii/S0959943611001246
TI - 1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy
T2 - Mendeleev Communications
AU - Vystorop, Igor V.
AU - Konovalova, Nina P
AU - Sashenkova, Tatyana E.
AU - Berseneva, Elena N
AU - Chernyak, A.V
AU - Fedorov, Boris S
AU - Kostyanovsky, Remir G
PY - 2011
DA - 2011/09/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 239-241
IS - 5
VL - 21
SN - 0959-9436
SN - 1364-551X
ER -
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@article{2011_Vystorop,
author = {Igor V. Vystorop and Nina P Konovalova and Tatyana E. Sashenkova and Elena N Berseneva and A.V Chernyak and Boris S Fedorov and Remir G Kostyanovsky},
title = {1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy},
journal = {Mendeleev Communications},
year = {2011},
volume = {21},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {sep},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0959943611001246},
number = {5},
pages = {239--241},
doi = {10.1016/j.mencom.2011.09.002}
}
Cite this
MLA
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Vystorop, Igor V., et al. “1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy.” Mendeleev Communications, vol. 21, no. 5, Sep. 2011, pp. 239-241. https://linkinghub.elsevier.com/retrieve/pii/S0959943611001246.