An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship
A.A. Yaroslavov
1
,
Anna A. Efimova
1
,
Galina N Rudenskaya
1
,
Irina D Grozdova
1
,
А. А. Ежов
2
,
S. N. Chvalun
3
,
Alevtina I Kulebyakina
3
,
Publication type: Journal Article
Publication date: 2017-05-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
A low-toxic ternary complex composed of anionic liposomes, cationic polylysine and slightly negative micelles from a polylactide– polyethylene glycol diblock copolymer is described. Liposomes with the encapsulated antitumor antibiotic Doxorubicin (Dox) retain their integrity after incorporation into the ternary complex. The incubation of cells with the Dox-loaded ternary complex leads to its penetration into the cells, the release of Dox from liposomes and predominant drug accumulation in cell nuclei. The ternary complex degrades to nanoparticles in the presence of proteolytic enzymes to produce low-toxic digestion products.
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Yaroslavov A. et al. An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship // Mendeleev Communications. 2017. Vol. 27. No. 3. pp. 299-301.
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Yaroslavov A., Efimova A. A., Rudenskaya G. N., Melik-Nubarov N. S., Grozdova I. D., Ежов А. А., Chvalun S. N., Kulebyakina A. I., Razuvaeva E. V. An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship // Mendeleev Communications. 2017. Vol. 27. No. 3. pp. 299-301.
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TY - JOUR
DO - 10.1016/j.mencom.2017.05.028
UR - https://linkinghub.elsevier.com/retrieve/pii/S0959943617301219
TI - An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship
T2 - Mendeleev Communications
AU - Yaroslavov, A.A.
AU - Efimova, Anna A.
AU - Rudenskaya, Galina N
AU - Melik-Nubarov, Nikolay S.
AU - Grozdova, Irina D
AU - Ежов, А. А.
AU - Chvalun, S. N.
AU - Kulebyakina, Alevtina I
AU - Razuvaeva, Ekaterina V
PY - 2017
DA - 2017/05/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 299-301
IS - 3
VL - 27
SN - 0959-9436
SN - 1364-551X
ER -
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BibTex (up to 50 authors)
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@article{2017_Yaroslavov,
author = {A.A. Yaroslavov and Anna A. Efimova and Galina N Rudenskaya and Nikolay S. Melik-Nubarov and Irina D Grozdova and А. А. Ежов and S. N. Chvalun and Alevtina I Kulebyakina and Ekaterina V Razuvaeva},
title = {An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship},
journal = {Mendeleev Communications},
year = {2017},
volume = {27},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {may},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0959943617301219},
number = {3},
pages = {299--301},
doi = {10.1016/j.mencom.2017.05.028}
}
Cite this
MLA
Copy
Yaroslavov, A.A., et al. “An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship.” Mendeleev Communications, vol. 27, no. 3, May. 2017, pp. 299-301. https://linkinghub.elsevier.com/retrieve/pii/S0959943617301219.