Oligoglycol carbonate prodrugs of 5-modified 2'-deoxyuridines: synthesis and antibacterial activity
Sergey D Negrya
1
,
Maxim V. Jasko
1
,
И. Л. Карпенко
1
,
Pavel N. Solyev
1
,
Vladimir O. Chekhov
1
,
Byasilya F Vasilieva
2
,
T A Efimenko
2
,
Liudmila A Alexandrova
1
Publication type: Journal Article
Publication date: 2022-07-01
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
In order to develop a new generation of antibacterial nucleosides, a representative set of novel 3 ' - and 5 ' -tri- or tetraethylene glycol prodrug forms of 5-alkyloxymethyl-2 ' - deoxyuridines was synthesized. These compounds were at least two orders of magnitude more soluble than the parent nucleosides, possessed significant inhibitory activity against a set of bacteria including resistant strains of Staphylococcus aureus and Mycobacterium smegmatis , and showed low cytotoxicity. The obtained data indicate that glycol carbonates are convenient and prospective for usage in prodrugs of nucleoside derivatives with antibacterial activity.
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Negrya S. D. et al. Oligoglycol carbonate prodrugs of 5-modified 2'-deoxyuridines: synthesis and antibacterial activity // Mendeleev Communications. 2022. Vol. 32. No. 4. pp. 433-435.
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Negrya S. D., Jasko M. V., Makarov D. A., Карпенко И. Л., Solyev P. N., Chekhov V. O., Ефременкова О. В., Vasilieva B. F., Efimenko T. A., Kochetkov S. N., Alexandrova L. A. Oligoglycol carbonate prodrugs of 5-modified 2'-deoxyuridines: synthesis and antibacterial activity // Mendeleev Communications. 2022. Vol. 32. No. 4. pp. 433-435.
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TY - JOUR
DO - 10.1016/j.mencom.2022.07.002
UR - https://linkinghub.elsevier.com/retrieve/pii/S0959943622001778
TI - Oligoglycol carbonate prodrugs of 5-modified 2'-deoxyuridines: synthesis and antibacterial activity
T2 - Mendeleev Communications
AU - Negrya, Sergey D
AU - Jasko, Maxim V.
AU - Makarov, Dmitriy A
AU - Карпенко, И. Л.
AU - Solyev, Pavel N.
AU - Chekhov, Vladimir O.
AU - Ефременкова, О. В.
AU - Vasilieva, Byasilya F
AU - Efimenko, T A
AU - Kochetkov, Sergey N.
AU - Alexandrova, Liudmila A
PY - 2022
DA - 2022/07/01
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 433-435
IS - 4
VL - 32
SN - 0959-9436
SN - 1364-551X
ER -
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BibTex (up to 50 authors)
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@article{2022_Negrya,
author = {Sergey D Negrya and Maxim V. Jasko and Dmitriy A Makarov and И. Л. Карпенко and Pavel N. Solyev and Vladimir O. Chekhov and О. В. Ефременкова and Byasilya F Vasilieva and T A Efimenko and Sergey N. Kochetkov and Liudmila A Alexandrova},
title = {Oligoglycol carbonate prodrugs of 5-modified 2'-deoxyuridines: synthesis and antibacterial activity},
journal = {Mendeleev Communications},
year = {2022},
volume = {32},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {jul},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0959943622001778},
number = {4},
pages = {433--435},
doi = {10.1016/j.mencom.2022.07.002}
}
Cite this
MLA
Copy
Negrya, Sergey D., et al. “Oligoglycol carbonate prodrugs of 5-modified 2'-deoxyuridines: synthesis and antibacterial activity.” Mendeleev Communications, vol. 32, no. 4, Jul. 2022, pp. 433-435. https://linkinghub.elsevier.com/retrieve/pii/S0959943622001778.