Nanomedicine: Nanotechnology, Biology, and Medicine

, volume 40 , pages 102493

Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye

Ekaterina N. Popova ¹

Victoria E. Tikhomirova ¹

Olga Beznos ²

Natalia Chesnokova ²

Yuri V Grigoriev ³

Natalia L. Klyachko ^{4, 5, 6}

Olga A Kost ⁷

Hide authors affiliations Show authors affiliations: 7 affiliations

Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia. |

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia. |

Shubnikov Institute of Crystallography, Federal Scientific Research Center Crystallography and Photonics , Russian Academy of Sciences , Moscow , Russia.

Kurchatov Complex of Crystallography and Photonics of NRC «Kurchatov Institute»

Shubnikov Institute of Crystallography

⁴

Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, 119991, Russia |

⁵

Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA |

⁶

Research Institute “Nanotechnology and Nanomaterials”, G.R. Derzhavin Tambov State University, 392000 Tambov, Russia |

⁷

Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia. Electronic address: |

Publication type: Journal Article

Publication date: 2022-02-01

Elsevier

Nanomedicine: Nanotechnology, Biology, and Medicine

scimago Q1

wos Q2

SJR: 0.950

CiteScore: 10.4

Impact factor: 4.6

ISSN: 15499634, 15499642

DOI: 10.1016/j.nano.2021.102493

Copy DOI

PubMed ID: 34775060

Medicine (miscellaneous)

Pharmaceutical Science

Molecular Medicine

General Materials Science

Bioengineering

Biomedical Engineering

Abstract

Formulations on the base of an inhibitor of angiotensin-converting enzyme, enalaprilat, were prepared by the inclusion of the drug into calcium phosphate (CaP)-particles in situ, followed by the covering of the particles with 5 kDa chitosan or 72 kDa glycol chitosan and cross-linking with sodium tripolyphosphate. Physicochemical characterization of the resulted hybrid particles was conducted using dynamic light scattering, as well as scanning and transmission electron microscopy. Enalaprilat-containing particles had a mean hydrodynamic diameter 180 nm and 260 nm and ζ-potential +7 mV and +16 mV for 5 kDa and 72 kDa chitosans, respectively. In vivo studies showed that enalaprilat within particles stayed longer in the tear fluid after single instillation and caused a significantly pronounced and prolonged decrease of intraocular pressure in rabbits, especially in the case of CaP-particles, covered by glycol chitosan. Thus, such formulations demonstrate potential as prospective therapeutic agents for the treatment of eye diseases.

Found

1 citation

Zvereva Maria

DSc in Chemistry, professor

102 publications, 1 295 citations

h-index: 19

Lomonosov Moscow State University

1 citation

Le-Deygen Irina

🥼 🤝

PhD in Chemistry

68 publications, 2 744 citations, 8 reviews

h-index: 19

Lomonosov Moscow State University

Research interests

Antibiotics

Chitosan

Drug delivery systems

Polymers for drug delivery

Proteins

1 citation

Yaminsky Igor

🥼 🤝

DSc in Physics and Mathematics, professor

200 publications, 3 670 citations

h-index: 23

Lomonosov Moscow State University

1 citation

Farahat Mohamed

PhD in Biological/biomedical sciences, associate professor

21 publications, 202 citations, 46 reviews

Microbial biotechnology

Microbiology

Nanotechnology

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GOST Copy

Popova E. V. et al. Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye // Nanomedicine: Nanotechnology, Biology, and Medicine. 2022. Vol. 40. p. 102493.

GOST all authors (up to 50) Copy

Popova E. N., Tikhomirova V. E., Beznos O., Chesnokova N., Grigoriev Y. V., Klyachko N. L., Kost O. A. Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye // Nanomedicine: Nanotechnology, Biology, and Medicine. 2022. Vol. 40. p. 102493.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.nano.2021.102493

UR - https://doi.org/10.1016/j.nano.2021.102493

TI - Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye

T2 - Nanomedicine: Nanotechnology, Biology, and Medicine

AU - Popova, Ekaterina N.

AU - Tikhomirova, Victoria E.

AU - Beznos, Olga

AU - Chesnokova, Natalia

AU - Grigoriev, Yuri V

AU - Klyachko, Natalia L.

AU - Kost, Olga A

PY - 2022

DA - 2022/02/01

PB - Elsevier

SP - 102493

VL - 40

PMID - 34775060

SN - 1549-9634

SN - 1549-9642

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Popova,

author = {Ekaterina N. Popova and Victoria E. Tikhomirova and Olga Beznos and Natalia Chesnokova and Yuri V Grigoriev and Natalia L. Klyachko and Olga A Kost},

title = {Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye},

journal = {Nanomedicine: Nanotechnology, Biology, and Medicine},

year = {2022},

volume = {40},

publisher = {Elsevier},

month = {feb},

url = {https://doi.org/10.1016/j.nano.2021.102493},

pages = {102493},

doi = {10.1016/j.nano.2021.102493}

}

Publisher

Elsevier

Journal

Nanomedicine: Nanotechnology, Biology, and Medicine

scimago Q1

wos Q2

SJR

0.950

CiteScore

10.4

Impact factor

4.6

ISSN

15499634 (Print)

15499642 (Electronic)

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