Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents
Тип публикации: Journal Article
Дата публикации: 2008-08-01
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 2.092
CiteScore: 13.2
Impact factor: 11.3
ISSN: 09447113, 1618095X
PubMed ID:
17976969
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Краткое описание
Cymbopogon winterianus (Poaceae) is used for its analgesic, anxiolytic and anticonvulsant properties in Brazilian folk medicine. This report aimed to perform phythochemical screening and to investigate the possible anticonvulsant effects of the essential oil (EO) from fresh leaves of C. winterianus in different models of epilepsy. The phytochemical analysis of EO showed presence of geraniol (40.06%), citronellal (27.44%) and citronellol (10.45%) as the main compounds. A behavioral screening demonstrated that EO (100, 200 and 400mg/kg; ip) caused depressant activity on CNS. When administered concurrently, EO (200 and 400mg/kg, ip) significantly reduced the number of animals that exhibited PTZ- and PIC-induced seizures in 50% of the experimental animals (p<0.05). Additionally, EO (100, 200 and 400mg/kg, ip) significantly increased (p<0.05) the latencies of clonic seizures induced by STR. Our results demonstrated a possible activity anticonvulsant of the EO.
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Quintans-Junior L. J. et al. Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents // Phytomedicine. 2008. Vol. 15. No. 8. pp. 619-624.
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Quintans-Junior L. J., Souza T. T., Leite B. S., Lessa N. M. N., Bonjardim L. R., Santos M. M., Alves P. P. D., Blank A. F., Antoniolli A. Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents // Phytomedicine. 2008. Vol. 15. No. 8. pp. 619-624.
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TY - JOUR
DO - 10.1016/j.phymed.2007.09.018
UR - https://doi.org/10.1016/j.phymed.2007.09.018
TI - Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents
T2 - Phytomedicine
AU - Quintans-Junior, Lucindo J
AU - Souza, Thais T
AU - Leite, B S
AU - Lessa, N M N
AU - Bonjardim, Leonardo R.
AU - Santos, Maria M.
AU - Alves, Paula P. D.
AU - Blank, Arie Fitzgerald
AU - Antoniolli, A.R
PY - 2008
DA - 2008/08/01
PB - Elsevier
SP - 619-624
IS - 8
VL - 15
PMID - 17976969
SN - 0944-7113
SN - 1618-095X
ER -
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@article{2008_Quintans-Junior,
author = {Lucindo J Quintans-Junior and Thais T Souza and B S Leite and N M N Lessa and Leonardo R. Bonjardim and Maria M. Santos and Paula P. D. Alves and Arie Fitzgerald Blank and A.R Antoniolli},
title = {Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents},
journal = {Phytomedicine},
year = {2008},
volume = {15},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.phymed.2007.09.018},
number = {8},
pages = {619--624},
doi = {10.1016/j.phymed.2007.09.018}
}
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MLA
Скопировать
Quintans-Junior, Lucindo J., et al. “Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents.” Phytomedicine, vol. 15, no. 8, Aug. 2008, pp. 619-624. https://doi.org/10.1016/j.phymed.2007.09.018.
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