A convergent approach to synthesis of bortezomib: the use of TBTU suppresses racemization in the fragment condensation
Тип публикации: Journal Article
Дата публикации: 2009-08-01
scimago Q3
wos Q2
БС2
SJR: 0.426
CiteScore: 4.1
Impact factor: 2.2
ISSN: 00404020, 14645416
Organic Chemistry
Drug Discovery
Biochemistry
Краткое описание
Bortezomib is a first-in-class therapeutic antineoplastic agent used for treating patients with multiple myeloma and mantle cell lymphoma. In this paper we report an improved method for synthesis of the title compound using a convergent approach. TBTU was found to efficiently suppress racemization in the fragment condensation. In comparison with the original synthesis, the presented one is shorter by two steps, higher in yield, and provides better atom economy.
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Ivanov A., Zhalnina A. A., Shishkov S. V. A convergent approach to synthesis of bortezomib: the use of TBTU suppresses racemization in the fragment condensation // Tetrahedron. 2009. Vol. 65. No. 34. pp. 7105-7108.
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Ivanov A., Zhalnina A. A., Shishkov S. V. A convergent approach to synthesis of bortezomib: the use of TBTU suppresses racemization in the fragment condensation // Tetrahedron. 2009. Vol. 65. No. 34. pp. 7105-7108.
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TY - JOUR
DO - 10.1016/j.tet.2009.06.042
UR - https://doi.org/10.1016/j.tet.2009.06.042
TI - A convergent approach to synthesis of bortezomib: the use of TBTU suppresses racemization in the fragment condensation
T2 - Tetrahedron
AU - Ivanov, Andrey
AU - Zhalnina, Anna A
AU - Shishkov, Sergey V
PY - 2009
DA - 2009/08/01
PB - Elsevier
SP - 7105-7108
IS - 34
VL - 65
SN - 0040-4020
SN - 1464-5416
ER -
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@article{2009_Ivanov,
author = {Andrey Ivanov and Anna A Zhalnina and Sergey V Shishkov},
title = {A convergent approach to synthesis of bortezomib: the use of TBTU suppresses racemization in the fragment condensation},
journal = {Tetrahedron},
year = {2009},
volume = {65},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.tet.2009.06.042},
number = {34},
pages = {7105--7108},
doi = {10.1016/j.tet.2009.06.042}
}
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MLA
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Ivanov, Andrey, et al. “A convergent approach to synthesis of bortezomib: the use of TBTU suppresses racemization in the fragment condensation.” Tetrahedron, vol. 65, no. 34, Aug. 2009, pp. 7105-7108. https://doi.org/10.1016/j.tet.2009.06.042.