Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone
2
Aberdeen Biomedical Imaging Centre, Lilian Sutton Building, Foresterhill, Aberdeen AB25 2ZD, UK
|
Publication type: Journal Article
Publication date: 2014-11-01
scimago Q3
wos Q2
SJR: 0.426
CiteScore: 4.1
Impact factor: 2.2
ISSN: 00404020, 14645416
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
A series of analogues of the integrin binding aspartic acid-glycine-arginine (RGD) peptide sequence were synthesised conjugated to nitric oxide (NO) donating functional groups. Also the cytotoxicity of abiraterone, a prostate cancer drug, was explored when it was conjugated in three part constructs to RGD sequences and NO releasing heterocycles. In general the analogues showed integrin binding affinity comparable to RGD reference compounds, and all released NO by the Griess test assay. Two analogues exhibited significant cytotoxic effects against PC3 and MCF7 cell lines.
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12
Total citations:
12
Citations from 2025:
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(8.33%)
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GOST
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Nortcliffe A. et al. Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone // Tetrahedron. 2014. Vol. 70. No. 44. pp. 8343-8347.
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Nortcliffe A., Fleming I. N., Botting N. P., O'Hagan D. Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone // Tetrahedron. 2014. Vol. 70. No. 44. pp. 8343-8347.
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RIS
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TY - JOUR
DO - 10.1016/j.tet.2014.09.004
UR - https://doi.org/10.1016/j.tet.2014.09.004
TI - Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone
T2 - Tetrahedron
AU - Nortcliffe, Andrew
AU - Fleming, Ian N.
AU - Botting, Nigel P.
AU - O'Hagan, David
PY - 2014
DA - 2014/11/01
PB - Elsevier
SP - 8343-8347
IS - 44
VL - 70
SN - 0040-4020
SN - 1464-5416
ER -
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BibTex (up to 50 authors)
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@article{2014_Nortcliffe,
author = {Andrew Nortcliffe and Ian N. Fleming and Nigel P. Botting and David O'Hagan},
title = {Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone},
journal = {Tetrahedron},
year = {2014},
volume = {70},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.tet.2014.09.004},
number = {44},
pages = {8343--8347},
doi = {10.1016/j.tet.2014.09.004}
}
Cite this
MLA
Copy
Nortcliffe, Andrew, et al. “Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone.” Tetrahedron, vol. 70, no. 44, Nov. 2014, pp. 8343-8347. https://doi.org/10.1016/j.tet.2014.09.004.