The first one-pot ambient-temperature synthesis of 1,2,4-oxadiazoles from amidoximes and carboxylic acid esters
Vladislava V Matveevskaya
1
,
Tatyana Sharonova
1
,
Anton A Shetnev
2
,
Sergey Rozhkov
1
,
Stanislav Kalinin
3
,
ALEXEY V. SMIRNOV
1
Publication type: Journal Article
Publication date: 2017-02-01
scimago Q3
wos Q2
SJR: 0.426
CiteScore: 4.1
Impact factor: 2.2
ISSN: 00404020, 14645416
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
The first one-pot room-temperature protocol for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles via the condensation between amidoximes and carboxylic acid esters in superbase medium MOH/DMSO is reported. A broad spectrum of alkyl, aryl and hetaryl amidoximes and esters was examined. This reaction route provides convenient access to 1,2,4-oxadiazoles, which is highly desirable because in the light of this privileged scaffold is recognized as an important core in the design of novel therapeutic agents and high-tech materials.
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GOST
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Matveevskaya V. V. et al. The first one-pot ambient-temperature synthesis of 1,2,4-oxadiazoles from amidoximes and carboxylic acid esters // Tetrahedron. 2017. Vol. 73. No. 7. pp. 945-951.
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Matveevskaya V. V., Sharonova T., Shetnev A. A., Rozhkov S., Kalinin S., SMIRNOV A. V. The first one-pot ambient-temperature synthesis of 1,2,4-oxadiazoles from amidoximes and carboxylic acid esters // Tetrahedron. 2017. Vol. 73. No. 7. pp. 945-951.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.tet.2017.01.007
UR - https://doi.org/10.1016/j.tet.2017.01.007
TI - The first one-pot ambient-temperature synthesis of 1,2,4-oxadiazoles from amidoximes and carboxylic acid esters
T2 - Tetrahedron
AU - Matveevskaya, Vladislava V
AU - Sharonova, Tatyana
AU - Shetnev, Anton A
AU - Rozhkov, Sergey
AU - Kalinin, Stanislav
AU - SMIRNOV, ALEXEY V.
PY - 2017
DA - 2017/02/01
PB - Elsevier
SP - 945-951
IS - 7
VL - 73
SN - 0040-4020
SN - 1464-5416
ER -
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BibTex (up to 50 authors)
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@article{2017_Matveevskaya,
author = {Vladislava V Matveevskaya and Tatyana Sharonova and Anton A Shetnev and Sergey Rozhkov and Stanislav Kalinin and ALEXEY V. SMIRNOV},
title = {The first one-pot ambient-temperature synthesis of 1,2,4-oxadiazoles from amidoximes and carboxylic acid esters},
journal = {Tetrahedron},
year = {2017},
volume = {73},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.tet.2017.01.007},
number = {7},
pages = {945--951},
doi = {10.1016/j.tet.2017.01.007}
}
Cite this
MLA
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Matveevskaya, Vladislava V., et al. “The first one-pot ambient-temperature synthesis of 1,2,4-oxadiazoles from amidoximes and carboxylic acid esters.” Tetrahedron, vol. 73, no. 7, Feb. 2017, pp. 945-951. https://doi.org/10.1016/j.tet.2017.01.007.
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