volume 57 issue 26 pages 2898-2900

A convenient and mild method for 1,2,4-oxadiazole preparation: cyclodehydration of O-acylamidoximes in the superbase system MOH/DMSO

Publication typeJournal Article
Publication date2016-06-01
scimago Q3
wos Q3
SJR0.334
CiteScore3.2
Impact factor1.5
ISSN00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Herein, we reported a general, convenient, and efficient synthesis of 3,5-disubstituted-1,2,4-oxadiazoles via cyclodehydration of O -acylamidoximes in the superbase system MOH/DMSO (M = Li, Na, K). Excellent isolated yields (up to 98%) were attained within short reaction times (10–20 min). In addition, mild reaction conditions and a simple work-up procedure allow the synthesis of a wide range of heat-labile 1,2,4-oxadiazole-containing substances.
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Matveevskaya V. V. et al. A convenient and mild method for 1,2,4-oxadiazole preparation: cyclodehydration of O-acylamidoximes in the superbase system MOH/DMSO // Tetrahedron Letters. 2016. Vol. 57. No. 26. pp. 2898-2900.
GOST all authors (up to 50) Copy
Matveevskaya V. V., Sharonova T., Osipyan A., Rozhkov S., Shetnev A. A., SMIRNOV A. V. A convenient and mild method for 1,2,4-oxadiazole preparation: cyclodehydration of O-acylamidoximes in the superbase system MOH/DMSO // Tetrahedron Letters. 2016. Vol. 57. No. 26. pp. 2898-2900.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.tetlet.2016.05.071
UR - https://doi.org/10.1016/j.tetlet.2016.05.071
TI - A convenient and mild method for 1,2,4-oxadiazole preparation: cyclodehydration of O-acylamidoximes in the superbase system MOH/DMSO
T2 - Tetrahedron Letters
AU - Matveevskaya, Vladislava V
AU - Sharonova, Tatyana
AU - Osipyan, Angelina
AU - Rozhkov, Sergey
AU - Shetnev, Anton A
AU - SMIRNOV, ALEXEY V.
PY - 2016
DA - 2016/06/01
PB - Elsevier
SP - 2898-2900
IS - 26
VL - 57
SN - 0040-4039
SN - 1873-3581
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2016_Matveevskaya,
author = {Vladislava V Matveevskaya and Tatyana Sharonova and Angelina Osipyan and Sergey Rozhkov and Anton A Shetnev and ALEXEY V. SMIRNOV},
title = {A convenient and mild method for 1,2,4-oxadiazole preparation: cyclodehydration of O-acylamidoximes in the superbase system MOH/DMSO},
journal = {Tetrahedron Letters},
year = {2016},
volume = {57},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.tetlet.2016.05.071},
number = {26},
pages = {2898--2900},
doi = {10.1016/j.tetlet.2016.05.071}
}
MLA
Cite this
MLA Copy
Matveevskaya, Vladislava V., et al. “A convenient and mild method for 1,2,4-oxadiazole preparation: cyclodehydration of O-acylamidoximes in the superbase system MOH/DMSO.” Tetrahedron Letters, vol. 57, no. 26, Jun. 2016, pp. 2898-2900. https://doi.org/10.1016/j.tetlet.2016.05.071.