TRAIL of Hope Meeting Resistance in Cancer
DAVID YB DENG
1
,
KHALID SHAH
1, 2
Publication type: Journal Article
Publication date: 2020-12-01
scimago Q1
wos Q1
SJR: 4.727
CiteScore: 25.5
Impact factor: 17.5
ISSN: 24058033, 24058025
PubMed ID:
32718904
Cancer Research
Oncology
Abstract
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis selectively via its interaction with the death receptors TRAILR1/DR4 and TRAILR2/DR5 in a wide range of cancers, while sparing normal cells. Despite its tremendous potential for cancer therapeutics, the translation of TRAIL into the clinic has been confounded by TRAIL-resistant cancer populations. We discuss different molecular mechanisms underlying TRAIL-mediated apoptosis and resistance to TRAIL. We also discuss the successes and failures of recent preclinical and clinical studies of TRAIL-induced apoptosis, and current attempts to overcome TRAIL resistance, and we provide a perspective for improving the prospects of future clinical implementation.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
|
|
|
International Journal of Molecular Sciences
6 publications, 5.94%
|
|
|
Cancers
4 publications, 3.96%
|
|
|
Cell Death and Disease
3 publications, 2.97%
|
|
|
Apoptosis : an international journal on programmed cell death
2 publications, 1.98%
|
|
|
International Journal of Pharmaceutics
2 publications, 1.98%
|
|
|
European Journal of Medicinal Chemistry
2 publications, 1.98%
|
|
|
Biomaterials
2 publications, 1.98%
|
|
|
FEBS Open Bio
2 publications, 1.98%
|
|
|
Experimental and Therapeutic Medicine
2 publications, 1.98%
|
|
|
Drug Resistance Updates
2 publications, 1.98%
|
|
|
Frontiers in Pharmacology
2 publications, 1.98%
|
|
|
Natural Product Communications
1 publication, 0.99%
|
|
|
Biomolecules
1 publication, 0.99%
|
|
|
Pharmaceutics
1 publication, 0.99%
|
|
|
Gels
1 publication, 0.99%
|
|
|
Frontiers in Medicine
1 publication, 0.99%
|
|
|
Frontiers in Immunology
1 publication, 0.99%
|
|
|
Frontiers in Cell and Developmental Biology
1 publication, 0.99%
|
|
|
Frontiers in Oncology
1 publication, 0.99%
|
|
|
Current Issues in Molecular Biology
1 publication, 0.99%
|
|
|
Nature Reviews Cancer
1 publication, 0.99%
|
|
|
Nature Communications
1 publication, 0.99%
|
|
|
Oncogene
1 publication, 0.99%
|
|
|
Food Research International
1 publication, 0.99%
|
|
|
iScience
1 publication, 0.99%
|
|
|
Chemico-Biological Interactions
1 publication, 0.99%
|
|
|
Pharmacological Research
1 publication, 0.99%
|
|
|
Journal of Biological Chemistry
1 publication, 0.99%
|
|
|
BioEssays
1 publication, 0.99%
|
|
|
1
2
3
4
5
6
|
Publishers
|
5
10
15
20
25
|
|
|
Elsevier
21 publications, 20.79%
|
|
|
Springer Nature
19 publications, 18.81%
|
|
|
MDPI
14 publications, 13.86%
|
|
|
Wiley
8 publications, 7.92%
|
|
|
Frontiers Media S.A.
7 publications, 6.93%
|
|
|
Taylor & Francis
5 publications, 4.95%
|
|
|
Royal Society of Chemistry (RSC)
3 publications, 2.97%
|
|
|
Cold Spring Harbor Laboratory
3 publications, 2.97%
|
|
|
American Chemical Society (ACS)
2 publications, 1.98%
|
|
|
Spandidos Publications
2 publications, 1.98%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
2 publications, 1.98%
|
|
|
OAE Publishing Inc.
2 publications, 1.98%
|
|
|
SAGE
1 publication, 0.99%
|
|
|
American Society for Biochemistry and Molecular Biology
1 publication, 0.99%
|
|
|
American Association for the Advancement of Science (AAAS)
1 publication, 0.99%
|
|
|
Hindawi Limited
1 publication, 0.99%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 0.99%
|
|
|
AME Publishing Company
1 publication, 0.99%
|
|
|
JMIR Publications
1 publication, 0.99%
|
|
|
Proceedings of the National Academy of Sciences (PNAS)
1 publication, 0.99%
|
|
|
Public Library of Science (PLoS)
1 publication, 0.99%
|
|
|
Research Square Platform LLC
1 publication, 0.99%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 0.99%
|
|
|
Walter de Gruyter
1 publication, 0.99%
|
|
|
American Association for Cancer Research (AACR)
1 publication, 0.99%
|
|
|
5
10
15
20
25
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
101
Total citations:
101
Citations from 2024:
42
(41.58%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.trecan.2020.06.006
UR - https://doi.org/10.1016/j.trecan.2020.06.006
TI - TRAIL of Hope Meeting Resistance in Cancer
T2 - Trends in Cancer
AU - DENG, DAVID YB
AU - SHAH, KHALID
PY - 2020
DA - 2020/12/01
PB - Elsevier
SP - 989-1001
IS - 12
VL - 6
PMID - 32718904
SN - 2405-8033
SN - 2405-8025
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_DENG,
author = {DAVID YB DENG and KHALID SHAH},
title = {TRAIL of Hope Meeting Resistance in Cancer},
journal = {Trends in Cancer},
year = {2020},
volume = {6},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.trecan.2020.06.006},
number = {12},
pages = {989--1001},
doi = {10.1016/j.trecan.2020.06.006}
}
Cite this
MLA
Copy
DENG, DAVID YB, et al. “TRAIL of Hope Meeting Resistance in Cancer.” Trends in Cancer, vol. 6, no. 12, Dec. 2020, pp. 989-1001. https://doi.org/10.1016/j.trecan.2020.06.006.