, volume 27 , issue 4 , pages 710-728

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery.

P. M. Kowalski ^{1, 2}

Miao Lei ³

Daniel S. Anderson ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA |

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. |

Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA 02142 USA |

Publication type: Journal Article

Publication date: 2019-04-01

Elsevier

Molecular Therapy

scimago Q1

wos Q1

SJR: 4.008

CiteScore: 20.1

Impact factor: 12.0

ISSN: 15250016, 15250024

DOI: 10.1016/j.ymthe.2019.02.012

Copy DOI

PubMed ID: 30846391

Drug Discovery

Molecular Biology

Pharmacology

Genetics

Molecular Medicine

Abstract

mRNA has broad potential as a therapeutic. Current clinical efforts are focused on vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical translation of mRNA therapeutics has been made possible through advances in the design of mRNA manufacturing and intracellular delivery methods. However, broad application of mRNA is still limited by the need for improved delivery systems. In this review, we discuss the challenges for clinical translation of mRNA-based therapeutics, with an emphasis on recent advances in biomaterials and delivery strategies, and we present an overview of the applications of mRNA-based delivery for protein therapy, gene editing, and vaccination.

Found

1 citation

Deviatkin Andrei

🥼 🤝

PhD in Biological/biomedical sciences

60 publications, 837 citations, 38 reviews

h-index: 15

Lomonosov Moscow State University

Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies

Molecular phylogenetics

Taxonomy

Virology

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GOST |

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GOST Copy

Kowalski P. M. et al. Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. // Molecular Therapy. 2019. Vol. 27. No. 4. pp. 710-728.

GOST all authors (up to 50) Copy

Kowalski P. M., Lei M., Anderson D. S. Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. // Molecular Therapy. 2019. Vol. 27. No. 4. pp. 710-728.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.ymthe.2019.02.012

UR - https://doi.org/10.1016/j.ymthe.2019.02.012

TI - Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery.

T2 - Molecular Therapy

AU - Kowalski, P. M.

AU - Lei, Miao

AU - Anderson, Daniel S.

PY - 2019

DA - 2019/04/01

PB - Elsevier

SP - 710-728

IS - 4

VL - 27

PMID - 30846391

SN - 1525-0016

SN - 1525-0024

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Kowalski,

author = {P. M. Kowalski and Miao Lei and Daniel S. Anderson},

title = {Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery.},

journal = {Molecular Therapy},

year = {2019},

volume = {27},

publisher = {Elsevier},

month = {apr},

url = {https://doi.org/10.1016/j.ymthe.2019.02.012},

number = {4},

pages = {710--728},

doi = {10.1016/j.ymthe.2019.02.012}

}

MLA

Cite this

MLA Copy

Kowalski, P. M., et al. “Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery..” Molecular Therapy, vol. 27, no. 4, Apr. 2019, pp. 710-728. https://doi.org/10.1016/j.ymthe.2019.02.012.

Publisher

Elsevier

Journal

Molecular Therapy

scimago Q1

wos Q1

SJR

4.008

CiteScore

20.1

Impact factor

12.0

ISSN

15250016 (Print)

15250024 (Electronic)