Zygote, volume 24, issue 2, pages 206-218
Expression and functional activity of neurotransmitter system components in sea urchins’ early development †
Nikishin Denis A
1, 2
,
Milošević Ivan
3
,
Gojković Milorad
3
,
Rakić Ljubisav
4
,
BEZUGLOV Vladimir V.
5
,
Shmukler Yuri B
1, 6
3
Institute of Marine Biology, Kotor, Montenegro.
|
4
Serbian Academy of Science and Art, Belgrade, Serbia.
|
6
26, Vavilov St, Moscow 119334, Russia
|
Publication type: Journal Article
Publication date: 2015-04-29
Cell Biology
Developmental Biology
Abstract
Summary
Reverse-transcription polymerase chain reaction (RT-PCR) investigation of the expression of the components supposedly taking part in serotonin regulation of the early development ofParacentrotus lividushas shown the presence of transcripts of five receptors, one of which has conservative amino acid residues characteristic of monoaminergic receptors. At the early stages of embryogenesis the expressions of serotonin transporter (SERT) and noradrenaline transporter (NET) were also recognized. The activities of the enzymes of serotonin synthesis and serotonin transporter were shown using immunohistochemistry and incubation with para-chlorophenylalanine (PСРА) and 5-hydroxytryptophan (HTP). Pharmacological experiments have shown a preferential cytostatic activity of ligands characterized as mammalian 5-hydroxytryptamine (5-HT)1-antagonists. On the basis of the sum of the data from molecular biology and embryo physiological experiments, it is suggested that metabotropic serotonin receptors and membrane transporters take part in the regulatory processes of early sea urchin embryogenesis.
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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The Royal Society
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1 publication, 11.11%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nikishin D. A. et al. Expression and functional activity of neurotransmitter system components in sea urchins’ early development † // Zygote. 2015. Vol. 24. No. 2. pp. 206-218.
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Nikishin D. A., Milošević I., Gojković M., Rakić L., BEZUGLOV V. V., Shmukler Y. B. Expression and functional activity of neurotransmitter system components in sea urchins’ early development † // Zygote. 2015. Vol. 24. No. 2. pp. 206-218.
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TY - JOUR
DO - 10.1017/S0967199415000040
UR - https://doi.org/10.1017%2FS0967199415000040
TI - Expression and functional activity of neurotransmitter system components in sea urchins’ early development †
T2 - Zygote
AU - Milošević, Ivan
AU - Gojković, Milorad
AU - Rakić, Ljubisav
AU - BEZUGLOV, Vladimir V.
AU - Nikishin, Denis A
AU - Shmukler, Yuri B
PY - 2015
DA - 2015/04/29 00:00:00
PB - Cambridge University Press
SP - 206-218
IS - 2
VL - 24
SN - 0967-1994
SN - 1469-8730
ER -
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@article{2015_Nikishin,
author = {Ivan Milošević and Milorad Gojković and Ljubisav Rakić and Vladimir V. BEZUGLOV and Denis A Nikishin and Yuri B Shmukler},
title = {Expression and functional activity of neurotransmitter system components in sea urchins’ early development †},
journal = {Zygote},
year = {2015},
volume = {24},
publisher = {Cambridge University Press},
month = {apr},
url = {https://doi.org/10.1017%2FS0967199415000040},
number = {2},
pages = {206--218},
doi = {10.1017/S0967199415000040}
}
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MLA
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Nikishin, Denis A., et al. “Expression and functional activity of neurotransmitter system components in sea urchins’ early development †.” Zygote, vol. 24, no. 2, Apr. 2015, pp. 206-218. https://doi.org/10.1017%2FS0967199415000040.
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