A triazole linkage that mimics the DNA phosphodiester group in living systems
Publication type: Journal Article
Publication date: 2015-07-16
scimago Q1
wos Q1
SJR: 2.036
CiteScore: 9.5
Impact factor: 5.3
ISSN: 00335835, 14698994
PubMed ID:
26537402
Biophysics
Abstract
We describe the development of a chemical process based on the CuAAC reaction (click chemistry) to ligate DNA strands and produce an unnatural triazole backbone linkage. The chemical reaction is templated by a complementary DNA splint which accelerates the reaction and provides the required specificity. The resultant 1,4-triazole linkage is read through by DNA and RNA polymerases and is biocompatible in bacterial and human cells. This work has implications for the synthesis of chemically modified genes and other large modified DNA and RNA constructs.
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Metrics
16
Total citations:
16
Citations from 2024:
6
(37.5%)
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MLA
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GOST
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El Sagheer A. H., BROWN T. A triazole linkage that mimics the DNA phosphodiester group in living systems // Quarterly Reviews of Biophysics. 2015. Vol. 48. No. 4. pp. 429-436.
GOST all authors (up to 50)
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El Sagheer A. H., BROWN T. A triazole linkage that mimics the DNA phosphodiester group in living systems // Quarterly Reviews of Biophysics. 2015. Vol. 48. No. 4. pp. 429-436.
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RIS
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TY - JOUR
DO - 10.1017/s0033583515000141
UR - https://doi.org/10.1017/s0033583515000141
TI - A triazole linkage that mimics the DNA phosphodiester group in living systems
T2 - Quarterly Reviews of Biophysics
AU - El Sagheer, Afaf H
AU - BROWN, Tom
PY - 2015
DA - 2015/07/16
PB - Cambridge University Press
SP - 429-436
IS - 4
VL - 48
PMID - 26537402
SN - 0033-5835
SN - 1469-8994
ER -
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BibTex (up to 50 authors)
Copy
@article{2015_El Sagheer,
author = {Afaf H El Sagheer and Tom BROWN},
title = {A triazole linkage that mimics the DNA phosphodiester group in living systems},
journal = {Quarterly Reviews of Biophysics},
year = {2015},
volume = {48},
publisher = {Cambridge University Press},
month = {jul},
url = {https://doi.org/10.1017/s0033583515000141},
number = {4},
pages = {429--436},
doi = {10.1017/s0033583515000141}
}
Cite this
MLA
Copy
El Sagheer, Afaf H., et al. “A triazole linkage that mimics the DNA phosphodiester group in living systems.” Quarterly Reviews of Biophysics, vol. 48, no. 4, Jul. 2015, pp. 429-436. https://doi.org/10.1017/s0033583515000141.