Organic Letters, volume 22, issue 9, pages 3318-3322
Photoredox-Catalyzed Four-Component Reaction for the Synthesis of Complex Secondary Amines
Lisa Marie Kammer
1
,
Matthias Krumb
1
,
Benjamin Spitzbarth
1
,
Benjamin Lipp
1
,
Jonas Kühlborn
1
,
Jonas Busold
1
,
O M Mulina
2
,
Publication type: Journal Article
Publication date: 2020-03-11
Journal:
Organic Letters
scimago Q1
wos Q1
SJR: 1.245
CiteScore: 9.3
Impact factor: 4.9
ISSN: 15237060, 15237052
PubMed ID:
32157890
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
The one-pot sulfonylation/aminoalkylation of styrene derivatives furnishing substituted γ-sulfonylamines was accomplished through a photoredox-catalyzed four-component reaction. Besides one molecule of water and the sodium counterion of the sulfinate, all atoms of the starting materials are transferred to the final product, rendering this process highly atom-efficient. The operationally simple protocol allows for the simultaneous formation of three new single bonds (C-S, C-N, and C-C) and therefore grants rapid access to structurally diverse products.
Found
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