Biomacromolecules

, том 22 , издание 2 , страницы 681-689

Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media

Irina M Le Deygen ¹

Oxana E Musatova ²

Victor Orlov ³

Nikolay S. Melik-Nubarov ²

Irina D Grozdova ²

Скрыть аффилиации авторов Показать аффилиации авторов: 3 аффилиации

Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University, GSP-1, Leninskie gory 1, build. 3, Moscow 119991, Russia |

Polymer Department, Faculty of Chemistry, Lomonosov Moscow State University, GSP-1, Leninskie gory 1, build. 3, Moscow 119991, Russia |

A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, GSP-1, Leninskie gory 1, Building 40, Moscow 119991, Russia |

Тип публикации: Journal Article

Дата публикации: 2020-12-16

American Chemical Society (ACS)

Biomacromolecules

scimago Q1

wos Q1

БС1

SJR: 1.142

CiteScore: 9.2

Impact factor: 5.4

ISSN: 15257797, 15264602

DOI: 10.1021/acs.biomac.0c01504

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PubMed ID: 33325680

Materials Chemistry

Polymers and Plastics

Bioengineering

Biomaterials

Краткое описание

We report here the first evidence for the interaction of poly(ethylene glycol) (PEG) with hyaluronan (HA) in aqueous solutions. PEG–HA complexes (Kapp = 45,000 ± 8000 M–1) contained about 3.3 ± 0.1 of ethylene glycol units per disaccharide of HA. The carboxyl of the D-glucuronic acid and the amide of the N-acetyl-D-glucosamine did not participate in PEG binding. Similar experiments performed with dextran and monosaccharides showed that multiple free primary hydroxyls regularly distributed along the polysaccharide chain are necessary for PEG binding. Another novelty of our study is contraction of HA upon PEG binding. The effect was observed with HA in solution or adsorbed on positively charged liposomes. The thickness of the HA layer on the liposomes decreased 2-fold upon PEG addition. HA compaction induced by PEG may underlie the changes in the plasma membrane properties and resealing of mechanical injuries induced by Pluronics.

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Московский государственный университет имени М.В. Ломоносова

Области научных интересов

Высокомолекулярные соединения

Доставка лекарств

Синтез амфифильных биодеградируемых сополимеров

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Химически индуцированная фотодинамическая терамия

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International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 20% International Journal of Molecular Sciences 2 публикации, 20%
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Polymer Chemistry	Polymer Chemistry, 1, 10% Polymer Chemistry 1 публикация, 10%
European Polymer Journal	European Polymer Journal, 1, 10% European Polymer Journal 1 публикация, 10%
Biomedicines	Biomedicines, 1, 10% Biomedicines 1 публикация, 10%
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Le Deygen I. M. et al. Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media // Biomacromolecules. 2020. Vol. 22. No. 2. pp. 681-689.

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Le Deygen I. M., Musatova O. E., Orlov V., Melik-Nubarov N. S., Grozdova I. D. Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media // Biomacromolecules. 2020. Vol. 22. No. 2. pp. 681-689.

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TY - JOUR

DO - 10.1021/acs.biomac.0c01504

UR - https://doi.org/10.1021/acs.biomac.0c01504

TI - Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media

T2 - Biomacromolecules

AU - Le Deygen, Irina M

AU - Musatova, Oxana E

AU - Orlov, Victor

AU - Melik-Nubarov, Nikolay S.

AU - Grozdova, Irina D

PY - 2020

DA - 2020/12/16

PB - American Chemical Society (ACS)

SP - 681-689

IS - 2

VL - 22

PMID - 33325680

SN - 1525-7797

SN - 1526-4602

ER -

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@article{2020_Le Deygen,

author = {Irina M Le Deygen and Oxana E Musatova and Victor Orlov and Nikolay S. Melik-Nubarov and Irina D Grozdova},

title = {Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media},

journal = {Biomacromolecules},

year = {2020},

volume = {22},

publisher = {American Chemical Society (ACS)},

month = {dec},

url = {https://doi.org/10.1021/acs.biomac.0c01504},

number = {2},

pages = {681--689},

doi = {10.1021/acs.biomac.0c01504}

}

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Le Deygen, Irina M., et al. “Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media.” Biomacromolecules, vol. 22, no. 2, Dec. 2020, pp. 681-689. https://doi.org/10.1021/acs.biomac.0c01504.