Overcoming Resistance to FLT3-ITD Therapeutics
Publication type: Journal Article
Publication date: 2024-12-12
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
39666851
Abstract
FLT3-ITD (internal tandem duplication) is a key driver of acute myeloid leukemia (AML), and several FDA-approved drugs target this mutant kinase. This Viewpoint describes the discovery of inhibitors targeting point mutants and the development of SILA123, a highly potent and selective type II FLT3 inhibitor. In in vivo studies, SILA-123 significantly suppressed tumor growth in allograft models, demonstrating its potential in treating resistant AML.
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2
Total citations:
2
Citations from 2024:
1
(50%)
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GOST
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McInnes C. Overcoming Resistance to FLT3-ITD Therapeutics // Journal of Medicinal Chemistry. 2024. Vol. 67. No. 24. pp. 21749-21751.
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McInnes C. Overcoming Resistance to FLT3-ITD Therapeutics // Journal of Medicinal Chemistry. 2024. Vol. 67. No. 24. pp. 21749-21751.
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RIS
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TY - JOUR
DO - 10.1021/acs.jmedchem.4c02878
UR - https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02878
TI - Overcoming Resistance to FLT3-ITD Therapeutics
T2 - Journal of Medicinal Chemistry
AU - McInnes, Campbell
PY - 2024
DA - 2024/12/12
PB - American Chemical Society (ACS)
SP - 21749-21751
IS - 24
VL - 67
PMID - 39666851
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (up to 50 authors)
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@article{2024_McInnes,
author = {Campbell McInnes},
title = {Overcoming Resistance to FLT3-ITD Therapeutics},
journal = {Journal of Medicinal Chemistry},
year = {2024},
volume = {67},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02878},
number = {24},
pages = {21749--21751},
doi = {10.1021/acs.jmedchem.4c02878}
}
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MLA
Copy
McInnes, Campbell. “Overcoming Resistance to FLT3-ITD Therapeutics.” Journal of Medicinal Chemistry, vol. 67, no. 24, Dec. 2024, pp. 21749-21751. https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02878.