University of South Carolina Sumter

Nandi S., Sarkis J., Hervani A.A., Helms M.M.

The COVID-19 pandemic has exposed businesses and societies to the shortfalls of normal patterns of production, consumption, and their long-lasting impact on supply chains. In this opinion paper, we provide insights from the COVID-19 pandemic for making supply chains more resilient, transparent, and sustainable. These insights include supply chains needing to develop localization, agility, and digitization (LAD) characteristics. We link LAD to a potential solution using blockchain technology and circular economy principle capabilities. Use cases are used to show how blockchain-enabled circular economy practices can support supply chain LAD efforts. Supply chain tracking, tracing, and responsiveness can be supported through blockchain-enabled circular economy practices. One result of identifying these relationships include solutions and insights at multiple levels and stakeholders - individual, organizational, supply chain, governmental, and community. These crisis-related observations and findings set a future research foundation for sustainable production and consumption.

Yuan J., Li M., Lv G., Lu Z.K.

AbstractObjectives As a global pandemic is inevitable, real-time monitoring of transmission is vital for containing the spread of COVID-19. The main objective of this study was to report the real-time effective reproduction numbers (R(t)) and case fatality rates (CFR) in Europe. Methods Data for this study were obtained mainly from the World Health Organization website, up to March 9, 2020. R(t) were estimated by exponential growth rate (EG) and time-dependent (TD) methods. ‘R0' package in R was employed to estimate R(t) by fitting the existing epidemic curve. Both the naïve CFR (nCFR) and adjusted CFR (aCFR) were estimated. Results With the EG method, R(t) was 3.27 (95% confidence interval (CI) 3.17–3.38) for Italy, 6.32 (95% CI 5.72–6.99) for France, 6.07 (95% CI 5.51–6.69) for Germany, and 5.08 (95% CI 4.51–5.74) for Spain. With the TD method, the R value for March 9 was 3.10 (95% CI 2.21–4.11) for Italy, 6.56 (95% CI 2.04–12.26) for France, 4.43 (95% CI 1.83–7.92) for Germany, and 3.95 (95% CI 0–10.19) for Spain. Conclusions This study provides important findings on the early outbreak of COVID-19 in Europe. Due to the recent rapid increase in new cases of COVID-19, real-time monitoring of the transmissibility and mortality in Spain and France is a priority.

Nandi M.L., Nandi S., Moya H., Kaynak H.

Purpose Using the resource-based theoretical view of the firm, this paper aims to explore how firms’ efforts to integrate blockchain technology (BCT) into their supply chain systems and activities enable certain supply chain capabilities and, consequently, improve their supply chain performance. Design/methodology/approach Using an abductive research approach, a qualitative content analysis was conducted on 126 cases of firms attempting to implement a blockchain technology-enabled supply chain system (BCTeSCS). These firms spanning across multiple industries were identified using the Nexis Uni database. Findings Findings reveal that present BCTeSCS efforts are more-oriented toward improving operational-level capabilities (information sharing and coordination capabilities) than strategic-level capabilities (integration and collaboration capabilities). These operational and strategic-level capabilities alongside BCTeSCS deliver several supply chains performance outcomes such as quality compliance and improvement, process improvement, flexibility, reduced cost and reduced process time. However, outcomes may vary by industry type based on their uncertainties. Research limitations/implications Given the nascent state of BCT, accessibility to primary data about ongoing BCTeSCS efforts is limited. The presented framework is based on 126 cases of secondary information. Within this constraint, the paper finds scope to future empirical research by proposing a resource-based framework of BCTeSCS and related propositions. Practical implications The results and discussion of this study serve as useful guidance for practitioners involved in BCTeSCS integrations. Social implications The paper creates a BCTeSCS scenario for stakeholders to assume its potential socio-economic and socio-environmental pressures. Originality/value This paper is one of the initial attempts to examine BCTeSCS efforts across multiple industries, and thus, promises a broad future research scope.

Nandi S., Sarkis J., Hervani A., Helms M.

PurposeUsing the resource-based and the resource dependence theoretical approaches of the firm, the paper explores firm responses to supply chain disruptions during COVID-19. The paper explores how firms develop localization, agility and digitization (L-A-D) capabilities by applying (or not applying) their critical circular economy (CE) and blockchain technology (BCT)-related resources and capabilities that they either already possess or acquire from external agents.Design/methodology/approachAn abductive approach, applying exploratory qualitative research was conducted over a sample of 24 firms. The sample represented different industries to study their critical BCT and CE resources and capabilities and the L-A-D capabilities. Firm resources and capabilities were classified using the technology, organization and environment (TOE) framework.FindingsFindings show significant patterns on adoption levels of the blockchain-enabled circular economy system (BCES) and L-A-D capability development. The greater the BCES adoption capabilities, the greater the L-A-D capabilities. Organizational size and industry both influence the relationship between BCES and L-A-D. Accordingly, research propositions and a research framework are proposed.Research limitations/implicationsGiven the limited sample size, the generalizability of the findings is limited. Our findings extend supply chain resiliency research. A series of propositions provide opportunities for future research. The resource-based view and resource-dependency theories are useful frameworks to better understanding the relationship between firm resources and supply chain resilience.Practical implicationsThe results and discussion of this study serve as useful guidance for practitioners to create CE and BCT resources and capabilities for improving supply chain resiliency.Social implicationsThe study shows the socio-economic and socio-environmental importance of BCES in the COVID-19 or similar crises.Originality/valueThe study is one of the initial attempts that highlights the possibilities of BCES across multiple industries and their value during pandemics and disruptions.

LaRowe D.E., Arndt S., Bradley J.A., Estes E.R., Hoarfrost A., Lang S.Q., Lloyd K.G., Mahmoudi N., Orsi W.D., Shah Walter S.R., Steen A.D., Zhao R.

Organic carbon in marine sediments is a critical component of the global carbon cycle, and its degradation influences a wide range of phenomena, including the magnitude of carbon sequestration over geologic timescales, the recycling of inorganic carbon and nutrients, the dissolution and precipitation of carbonates, the production of methane and the nature of the seafloor biosphere. Although much has been learned about the factors that promote and hinder rates of organic carbon degradation in natural systems, the controls on the distribution of organic carbon in modern and ancient sediments are still not fully understood. In this review, we summarize how recent findings are changing entrenched perspectives on organic matter degradation in marine sediments: a shift from a structurally-based chemical reactivity viewpoint towards an emerging acceptance of the role of the ecosystem in organic matter degradation rates. That is, organic carbon has a range of reactivities determined by not only the nature of the organic compounds, but by the biological, geochemical, and physical attributes of its environment. This shift in mindset has gradually come about due to a greater diversity of sample sites, the molecular revolution in biology, discoveries concerning the extent and limits of life, advances in quantitative modeling, investigations of ocean carbon cycling under a variety of extreme paleo-conditions (e.g. greenhouse environments, euxinic/anoxic oceans), the application of novel analytical techniques and interdisciplinary efforts. Adopting this view across scientific disciplines will enable additional progress in understanding how marine sediments influence the global carbon cycle.

Zhao X., Liu L., An T., Xian M., Luckanagul J.A., Su Z., Lin Y., Wang Q.

For wounds with heavy exudate levels, a dressing that can help to absorb wound exudate and improve the wound healing process is highly desired. Hydrogen sulfide (H2S) has been recognized as an important gasotransmitter that can improve angiogenesis which is crucial for wound healing. In this study, a functional sodium alginate (SA) dressing with H2S-releasing property (SA/JK-1) was fabricated by incorporating JK-1 molecule, a pH-dependent H2S donor, into SA sponge. The resultant SA/JK-1 sponge provided a moist and protective healing environment and was capable of releasing H2S consistently under acidic pH condition by absorbing exudate at the wound interface. The H2S release of JK-1 donor was prolonged by the SA sponge compared with JK-1 in solution. Cell study in vitro indicated that SA/JK-1 not only exhibited good cyto-compatibility, but also improved fibroblast proliferation and migration. In addition, the effects of the SA/JK-1 dressing on wound healing was evaluated using an in vivo full thickness dermal defect model, which revealed that SA/JK-1 can significantly improve wound healing process with enhanced granulation tissue formation, re-epithelialization, collagen deposition and angiogenesis, due to the H2S released from JK-1. Taken together, our results showed that SA dressing doped with H2S donor could potentially serves as an effective wound healing strategy. STATEMENT OF SIGNIFICANCE: The gasotransmitter H2S has been proven to improve the wound healing process in nanofibrous dressing due to its biological functions on angiogenesis. However, for non-healing wounds with heavy exudates, a wound dressing that can absorb wound exudates and controlled gasotransmitter release to improve the wound healing process is still in urgent need. Here we fabricated a sodium alginate (SA) sponge incorporated with H2S donor JK-1 (SA/JK-1), which showed strong water uptake capability, and released H2S under acidic condition. The SA/JK-1 sponge exhibited biocompatibility to fibroblasts and promoted cell migration in vitro, and exhibited obviously positive influence on wound healing in vivo. This H2S donor doped alginate wound dressing represents a promising strategy for treatment of non-healing wound.

Huang R., Shen Y., Guan Y., Jiang Y., Wu Y., Rahman K., Zhang L., Liu H., Luan X.

Mesoporous silica nanoparticles (MSNs) have received increasing interest due to their tunable particle size, large surface area, stable framework, and easy surface modification. They are increasingly being used in varying applications as delivery vehicles including bio-imaging, drug delivery, biosensors and tissue engineering etc. Precise structure control and the ability to modify surface properties of MSNs are important for their applications. This review summarises the different synthetic methods for the preparation of well-ordered MSNs with tunable pore volume as well as the approaches of drugs loading, especially highlighting the facile surface functionalization for various purposes and versatile biomedical applications in oncology. Finally, the challenges of clinical transformation of MSNs-based nanomedicines are further discussed.

Kim J.K., Overton H., Bhalla N., Li J.

This study applies arguments from attribution theory to examine the role of perceived motives (values-driven, egoistic-driven, strategic-driven, and stakeholder-driven motives) in developing individuals’ attitudes, positive word-of-mouth (PWOM), and negative word-of-mouth (NWOM) intentions in response to Nike’s 30th Anniversary ad campaign featuring Colin Kaepernick. This study also examines how perceptions of the appropriateness of the politicization of sports moderate these relationships, as well as individual factors that predict people’s assessments of sports as a politicized event. A survey (N = 373) was conducted to examine how much people’s perceptions of Nike’s motives for engaging in Corporate Social Advocacy (CSA) guided their responses and the degree to which they were likely to engage in actions. Implications for theory and practice are discussed.

Saatci O., Huynh-Dam K., Sahin O.

Estrogen receptor-positive (ER +) breast cancer accounts for approximately 75% of all breast cancers. Endocrine therapies, including selective ER modulators (SERMs), aromatase inhibitors (AIs), and selective ER down-regulators (SERDs) provide substantial clinical benefit by reducing the risk of disease recurrence and mortality. However, resistance to endocrine therapies represents a major challenge, limiting the success of ER + breast cancer treatment. Mechanisms of endocrine resistance involve alterations in ER signaling via modulation of ER (e.g., ER downregulation, ESR1 mutations or fusions); alterations in ER coactivators/corepressors, transcription factors (TFs), nuclear receptors and epigenetic modulators; regulation of signaling pathways; modulation of cell cycle regulators; stress signaling; and alterations in tumor microenvironment, nutrient stress, and metabolic regulation. Current therapeutic strategies to improve outcome of endocrine-resistant patients in clinics include inhibitors against mechanistic target of rapamycin (mTOR), cyclin-dependent kinase (CDK) 4/6, and the phosphoinositide 3-kinase (PI3K) subunit, p110α. Preclinical studies reveal novel therapeutic targets, some of which are currently tested in clinical trials as single agents or in combination with endocrine therapies, such as ER partial agonists, ER proteolysis targeting chimeras (PROTACs), next-generation SERDs, AKT inhibitors, epidermal growth factor receptor 1 and 2 (EGFR/HER2) dual inhibitors, HER2 targeting antibody-drug conjugates (ADCs) and histone deacetylase (HDAC) inhibitors. In this review, we summarize the established and emerging mechanisms of endocrine resistance, alterations during metastatic recurrence, and discuss the approved therapies and ongoing clinical trials testing the combination of novel targeted therapies with endocrine therapy in endocrine-resistant ER + breast cancer patients.

Blahut M., Sanchez E., Fisher C.E., Outten F.W.

Biogenesis of iron-sulfur (FeS) clusters in an essential process in living organisms due to the critical role of FeS cluster proteins in myriad cell functions. During biogenesis of FeS clusters, multi-protein complexes are used to drive the mobilization and protection of reactive sulfur and iron intermediates, regulate assembly of various FeS clusters on an ATPase-dependent, multi-protein scaffold, and target nascent clusters to their downstream protein targets. The evolutionarily ancient sulfur formation (Suf) pathway for FeS cluster assembly is found in bacteria and archaea. In Escherichia coli, the Suf pathway functions as an emergency pathway under conditions of iron limitation or oxidative stress. In other pathogenic bacteria, such as Mycobacterium tuberculosis and Enterococcus faecalis, the Suf pathway is the sole source for FeS clusters and therefore is a potential target for the development of novel antibacterial compounds. Here we summarize the considerable progress that has been made in characterizing the first step of mobilization and protection of reactive sulfur carried out by the SufS-SufE or SufS-SufU complex, FeS cluster assembly on SufBC2D scaffold complexes, and the downstream trafficking of nascent FeS clusters to A-type carrier (ATC) proteins. Cell Biology of Metals III edited by Roland Lill and Mick Petris.