Journal of Medicinal Chemistry, volume 63, issue 6, pages 3227-3237

Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains

Rezaul Md Karim ^{1, 2}

Alice Chan ¹

朱进一 Zhu Jinyi ¹

Ernst Schönbrunn ^{1, 2}

Department of Drug Discovery, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, United States |

Department of Molecular Medicine, USF Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States |

Publication type: Journal Article

Publication date: 2020-02-24

American Chemical Society (ACS)

Journal: Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR: 1.986

CiteScore: 12.8

Impact factor: 6.8

ISSN: 00222623, 15204804

DOI: 10.1021/acs.jmedchem.9b01980

Copy DOI

PubMed ID: 32091206

Drug Discovery

Molecular Medicine

Abstract

Inhibition of the bromodomain containing protein 9 (BRD9) by small molecules is an attractive strategy to target mutated SWI/SNF chromatin-remodeling complexes in cancer. However, reported BRD9 inh...

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Publisher

American Chemical Society (ACS)

Journal

Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR

1.986

CiteScore

12.8

Impact factor

6.8

ISSN

00222623 (Print)

15204804 (Electronic)

Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains

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