Lasiodiplodiapyrones A and B, Pyrone–Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae
Тип публикации: Journal Article
Дата публикации: 2023-01-06
SCImago Q1
WOS Q2
БС1
SJR: 0.585
CiteScore: 6.3
Impact factor: 3.7
ISSN: 01633864, 15206025
PubMed ID:
36607819
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Краткое описание
Lasiodiplodiapyrones A and B (1 and 2), two new preussomerin derivatives, possessing an unexpected 6-methyl-4H-furo[3,2-c]pyran-4-one moiety and a highly functionalized conjoint and complicated polycyclic ring system, along with two known congeners (3 and 4), were isolated from the fungus Lasiodiplodia pseudotheobromae. Their structures including absolute configurations were determined by spectroscopic analyses, Mosher's method, and ECD calculations. A biosynthetic pathway was proposed to explain the origin of lasiodiplodiapyrones A and B as well as their relationship with preussomerins. Compounds 1–4 showed suppressive effects on the production of NO with IC50 values of 4.8 ± 0.3, 8.5 ± 1.1, 5.9 ± 0.8, and 12.8 ± 1.3 μM, respectively.
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11
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(54.54%)
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ГОСТ
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Liang Yu. et al. Lasiodiplodiapyrones A and B, Pyrone–Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae // Journal of Natural Products. 2023. Vol. 86. No. 1. pp. 18-23.
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Liang Yu., Li Q., Li Y., Zheng Y., Shen Y., Yang H., Lu Y., Liu J., Zhou Q., Li D., Sun W., Zhu H., Chen C., Chen C., Zhang Y. Lasiodiplodiapyrones A and B, Pyrone–Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae // Journal of Natural Products. 2023. Vol. 86. No. 1. pp. 18-23.
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TY - JOUR
DO - 10.1021/acs.jnatprod.2c00530
UR - https://pubs.acs.org/doi/10.1021/acs.jnatprod.2c00530
TI - Lasiodiplodiapyrones A and B, Pyrone–Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae
T2 - Journal of Natural Products
AU - Liang, Yu
AU - Li, Qin
AU - Li, Yongqi
AU - Zheng, Yuyi
AU - Shen, Yong
AU - Yang, Haojie
AU - Lu, Yuling
AU - Liu, Jun-Jun
AU - Zhou, Qun
AU - Li, Dongyan
AU - Sun, Weiguang
AU - Zhu, Hucheng
AU - Chen, Chunmei
AU - Chen, Chun-Mei
AU - Zhang, Yonghui
PY - 2023
DA - 2023/01/06
PB - American Chemical Society (ACS)
SP - 18-23
IS - 1
VL - 86
PMID - 36607819
SN - 0163-3864
SN - 1520-6025
ER -
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@article{2023_Liang,
author = {Yu Liang and Qin Li and Yongqi Li and Yuyi Zheng and Yong Shen and Haojie Yang and Yuling Lu and Jun-Jun Liu and Qun Zhou and Dongyan Li and Weiguang Sun and Hucheng Zhu and Chunmei Chen and Chun-Mei Chen and Yonghui Zhang},
title = {Lasiodiplodiapyrones A and B, Pyrone–Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae},
journal = {Journal of Natural Products},
year = {2023},
volume = {86},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://pubs.acs.org/doi/10.1021/acs.jnatprod.2c00530},
number = {1},
pages = {18--23},
doi = {10.1021/acs.jnatprod.2c00530}
}
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MLA
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Liang, Yu., et al. “Lasiodiplodiapyrones A and B, Pyrone–Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae.” Journal of Natural Products, vol. 86, no. 1, Jan. 2023, pp. 18-23. https://pubs.acs.org/doi/10.1021/acs.jnatprod.2c00530.
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