Meroantarctines A–C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity
Тип публикации: Journal Article
Дата публикации: 2022-11-22
scimago Q1
wos Q1
БС1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
36413729
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Краткое описание
New meroterpenoids, meroantarctines A–C (1–3), with unique 6/5/6/6, 6/5/6/5/6, and 6/5/6/5 polycyclic systems were isolated from the alga-derived fungus Penicillium antarcticum KMM 4685. Their structures were elucidated by spectroscopic methods, X-ray diffraction, and quantum chemical calculations. A biogenetic pathway for 1–3 was proposed. Meroantarctines A–C (1–3) inhibited p-glycoprotein activity and could resensitize drug-resistant cancer cells to docetaxel.
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Leshchenko E. V. et al. Meroantarctines A–C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity // Journal of Natural Products. 2022. Vol. 85. No. 12. pp. 2746-2752.
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Leshchenko E. V., Antonov A. S., Dyshlovoy S. A., Berdyshev D. V., Hauschild J., Zhuravleva O. I., Borkunov G. V., Menshov A. S., Kirichuk N. N., Popov R. S., Gerasimenko A. V., Udovenko A. A., Graefen M., Bokemeyer C., von Amsberg G., Yurchenko A. N. Meroantarctines A–C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity // Journal of Natural Products. 2022. Vol. 85. No. 12. pp. 2746-2752.
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TY - JOUR
DO - 10.1021/acs.jnatprod.2c00677
UR - https://doi.org/10.1021/acs.jnatprod.2c00677
TI - Meroantarctines A–C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity
T2 - Journal of Natural Products
AU - Leshchenko, Elena V
AU - Antonov, Alexandr S.
AU - Dyshlovoy, Sergey A.
AU - Berdyshev, Dmitrii V
AU - Hauschild, Jessica
AU - Zhuravleva, Olesya I
AU - Borkunov, Gleb V
AU - Menshov, Alexander S
AU - Kirichuk, Natalya N
AU - Popov, Roman S
AU - Gerasimenko, Andrey V
AU - Udovenko, Anatoly A.
AU - Graefen, Markus
AU - Bokemeyer, Carsten
AU - von Amsberg, Gunhild
AU - Yurchenko, Anton N
PY - 2022
DA - 2022/11/22
PB - American Chemical Society (ACS)
SP - 2746-2752
IS - 12
VL - 85
PMID - 36413729
SN - 0163-3864
SN - 1520-6025
ER -
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@article{2022_Leshchenko,
author = {Elena V Leshchenko and Alexandr S. Antonov and Sergey A. Dyshlovoy and Dmitrii V Berdyshev and Jessica Hauschild and Olesya I Zhuravleva and Gleb V Borkunov and Alexander S Menshov and Natalya N Kirichuk and Roman S Popov and Andrey V Gerasimenko and Anatoly A. Udovenko and Markus Graefen and Carsten Bokemeyer and Gunhild von Amsberg and Anton N Yurchenko},
title = {Meroantarctines A–C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity},
journal = {Journal of Natural Products},
year = {2022},
volume = {85},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/acs.jnatprod.2c00677},
number = {12},
pages = {2746--2752},
doi = {10.1021/acs.jnatprod.2c00677}
}
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Leshchenko, Elena V., et al. “Meroantarctines A–C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity.” Journal of Natural Products, vol. 85, no. 12, Nov. 2022, pp. 2746-2752. https://doi.org/10.1021/acs.jnatprod.2c00677.