Langmuir, volume 33, issue 14, pages 3517-3524

Line Activity of Ganglioside GM1 Regulates the Raft Size Distribution in a Cholesterol-Dependent Manner

Galimzyanov T. ^{1, 2}

Lyushnyak A S ^{1, 3}

Aleksandrova V V ²

Shilova L A ^{1, 3}

Mikhalyov I I ⁴

Molotkovskaya I M ⁴

Akimov Sergey ^{1, 2}

Batishchev Oleg ^{1, 3}

Hide authors affiliations Show authors affiliations: 4 affiliations

A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31/4 Leninskii Prospekt, Moscow, 119071 Russia |

National University of Science and Technology “MISiS”, 4 Leninskii Prospekt, Moscow, 119049 Russia |

Moscow Institute of Physics and Technology, 9 Institutskii per., Dolgoprudnyi, Moscow Region, 141700 Russia |

⁴

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya Str., Moscow, 117997 Russia |

Publication type: Journal Article

Publication date: 2017-03-29

American Chemical Society (ACS)

Journal: Langmuir

Quartile SCImago

Quartile WOS

Impact factor: 3.9

ISSN: 07437463, 15205827

DOI: 10.1021/acs.langmuir.7b00404

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Spectroscopy

Electrochemistry

Condensed Matter Physics

General Materials Science

Surfaces and Interfaces

Abstract

Liquid-ordered lipid domains, also called rafts, are assumed to be important players in different cellular processes, mainly signal transduction and membrane trafficking. They are thicker than the disordered part of the membrane and are thought to form to compensate for the hydrophobic mismatch between transmembrane proteins and the lipid environment. Despite the existence of such structures in vivo still being an open question, they are observed in model systems of multicomponent lipid bilayers. Moreover, the predictions obtained from model experiments allow the explanation of different physiological processes possibly involving rafts. Here we present the results of the study of the regulation of raft size distribution by ganglioside GM1. Combining atomic force microscopy with theoretical considerations based on the theory of membrane elasticity, we predict that this glycolipid should change the line tension of raft boundaries in two different ways, mainly depending on the cholesterol content. These results explain the shedding of gangliosides from the surface of tumor cells and the following ganglioside-induced apoptosis of T-lymphocytes in a raft-dependent manner. Moreover, the generality of the model allows the prediction of the line activity of different membrane components based on their molecular geometry.

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Citations by journals

	1 2 3 4 5 6 7
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology	Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 7, 19.44% Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology 7 publications, 19.44%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 5, 13.89% International Journal of Molecular Sciences 5 publications, 13.89%
Membranes	Membranes, 5, 13.89% Membranes 5 publications, 13.89%
Physical Review E	Physical Review E, 4, 11.11% Physical Review E 4 publications, 11.11%
Biomolecules	Biomolecules, 2, 5.56% Biomolecules 2 publications, 5.56%
Journal of Chemical Physics	Journal of Chemical Physics, 1, 2.78% Journal of Chemical Physics 1 publication, 2.78%
Physical Review Letters	Physical Review Letters, 1, 2.78% Physical Review Letters 1 publication, 2.78%
Journal of Applied Crystallography	Journal of Applied Crystallography, 1, 2.78% Journal of Applied Crystallography 1 publication, 2.78%
Experimental and Therapeutic Medicine	Experimental and Therapeutic Medicine, 1, 2.78% Experimental and Therapeutic Medicine 1 publication, 2.78%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 1, 2.78% Frontiers in Molecular Biosciences 1 publication, 2.78%
Scientific Reports	Scientific Reports, 1, 2.78% Scientific Reports 1 publication, 2.78%
Biochimica et Biophysica Acta - Biomembranes	Biochimica et Biophysica Acta - Biomembranes, 1, 2.78% Biochimica et Biophysica Acta - Biomembranes 1 publication, 2.78%
Biochimica et Biophysica Acta - General Subjects	Biochimica et Biophysica Acta - General Subjects, 1, 2.78% Biochimica et Biophysica Acta - General Subjects 1 publication, 2.78%
FEBS Letters	FEBS Letters, 1, 2.78% FEBS Letters 1 publication, 2.78%
Russian Journal of Physical Chemistry A	Russian Journal of Physical Chemistry A, 1, 2.78% Russian Journal of Physical Chemistry A 1 publication, 2.78%
Methods in Enzymology	Methods in Enzymology, 1, 2.78% Methods in Enzymology 1 publication, 2.78%
Advances in Experimental Medicine and Biology	Advances in Experimental Medicine and Biology, 1, 2.78% Advances in Experimental Medicine and Biology 1 publication, 2.78%
Molecules	Molecules, 1, 2.78% Molecules 1 publication, 2.78%
	1 2 3 4 5 6 7

Citations by publishers

	2 4 6 8 10 12 14
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 13, 36.11% Multidisciplinary Digital Publishing Institute (MDPI) 13 publications, 36.11%
Pleiades Publishing	Pleiades Publishing, 8, 22.22% Pleiades Publishing 8 publications, 22.22%
American Physical Society (APS)	American Physical Society (APS), 5, 13.89% American Physical Society (APS) 5 publications, 13.89%
Elsevier	Elsevier, 3, 8.33% Elsevier 3 publications, 8.33%
Springer Nature	Springer Nature, 2, 5.56% Springer Nature 2 publications, 5.56%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 1, 2.78% American Institute of Physics (AIP) 1 publication, 2.78%
International Union of Crystallography (IUCr)	International Union of Crystallography (IUCr), 1, 2.78% International Union of Crystallography (IUCr) 1 publication, 2.78%
Spandidos Publications	Spandidos Publications, 1, 2.78% Spandidos Publications 1 publication, 2.78%
Frontiers Media S.A.	Frontiers Media S.A., 1, 2.78% Frontiers Media S.A. 1 publication, 2.78%
Wiley	Wiley, 1, 2.78% Wiley 1 publication, 2.78%
	2 4 6 8 10 12 14

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Galimzyanov T. et al. Line Activity of Ganglioside GM1 Regulates the Raft Size Distribution in a Cholesterol-Dependent Manner // Langmuir. 2017. Vol. 33. No. 14. pp. 3517-3524.

GOST all authors (up to 50) Copy

Galimzyanov T., Lyushnyak A. S., Aleksandrova V. V., Shilova L. A., Mikhalyov I. I., Molotkovskaya I. M., Akimov S., Batishchev O. Line Activity of Ganglioside GM1 Regulates the Raft Size Distribution in a Cholesterol-Dependent Manner // Langmuir. 2017. Vol. 33. No. 14. pp. 3517-3524.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acs.langmuir.7b00404

UR - https://doi.org/10.1021%2Facs.langmuir.7b00404

TI - Line Activity of Ganglioside GM1 Regulates the Raft Size Distribution in a Cholesterol-Dependent Manner

T2 - Langmuir

AU - Lyushnyak, A S

AU - Aleksandrova, V V

AU - Shilova, L A

AU - Mikhalyov, I I

AU - Molotkovskaya, I M

AU - Batishchev, Oleg

AU - Galimzyanov, T.

AU - Akimov, Sergey

PY - 2017

DA - 2017/03/29 00:00:00

PB - American Chemical Society (ACS)

SP - 3517-3524

IS - 14

VL - 33

SN - 0743-7463

SN - 1520-5827

ER -

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@article{2017_Galimzyanov,

author = {A S Lyushnyak and V V Aleksandrova and L A Shilova and I I Mikhalyov and I M Molotkovskaya and Oleg Batishchev and T. Galimzyanov and Sergey Akimov},

title = {Line Activity of Ganglioside GM1 Regulates the Raft Size Distribution in a Cholesterol-Dependent Manner},

journal = {Langmuir},

year = {2017},

volume = {33},

publisher = {American Chemical Society (ACS)},

month = {mar},

url = {https://doi.org/10.1021%2Facs.langmuir.7b00404},

number = {14},

pages = {3517--3524},

doi = {10.1021/acs.langmuir.7b00404}

}

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Galimzyanov, T., et al. “Line Activity of Ganglioside GM1 Regulates the Raft Size Distribution in a Cholesterol-Dependent Manner.” Langmuir, vol. 33, no. 14, Mar. 2017, pp. 3517-3524. https://doi.org/10.1021%2Facs.langmuir.7b00404.

Found error?

Publisher

American Chemical Society (ACS)

Journal

Langmuir

Quartile SCImago

Quartile WOS

Impact factor

3.9

ISSN

07437463 (Print)
15205827 (Electronic)

Labs

Bioelectrochemistry Laboratory

Profiles

Batishchev, Oleg Vyacheslavovich