A Pot-Economical Approach to the Total Synthesis of Sch-725674
Publication type: Journal Article
Publication date: 2016-01-13
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
26760683
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
A pot-economical total synthesis of antifungal Sch-725674, 1, is reported. The approach takes advantage of a number of one-pot, sequential transformations, including a phosphate tether-mediated one-pot, sequential RCM/CM/chemoselective hydrogenation protocol, a one-pot tosylation/acrylation sequence, and a one-pot, sequential Finkelstein reaction/Boord olefination/acetonide deprotection procedure to streamline the synthesis route by reducing isolation and purification procedures, thus saving time. Overall, an asymmetric route has been developed that is efficiently accomplished in seven pots from phosphate (S,S)-triene and with minimal purification.
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Total citations:
24
Citations from 2024:
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(4.17%)
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GOST
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Mahipal B. et al. A Pot-Economical Approach to the Total Synthesis of Sch-725674 // Organic Letters. 2016. Vol. 18. No. 3. pp. 516-519.
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Mahipal B., Javed S., Ganguly A., Torres J., Hanson P. R. A Pot-Economical Approach to the Total Synthesis of Sch-725674 // Organic Letters. 2016. Vol. 18. No. 3. pp. 516-519.
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RIS
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TY - JOUR
DO - 10.1021/acs.orglett.5b03547
UR - https://doi.org/10.1021/acs.orglett.5b03547
TI - A Pot-Economical Approach to the Total Synthesis of Sch-725674
T2 - Organic Letters
AU - Mahipal, Bodugam
AU - Javed, Salim
AU - Ganguly, Arghya
AU - Torres, Jessica
AU - Hanson, Paul R.
PY - 2016
DA - 2016/01/13
PB - American Chemical Society (ACS)
SP - 516-519
IS - 3
VL - 18
PMID - 26760683
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Mahipal,
author = {Bodugam Mahipal and Salim Javed and Arghya Ganguly and Jessica Torres and Paul R. Hanson},
title = {A Pot-Economical Approach to the Total Synthesis of Sch-725674},
journal = {Organic Letters},
year = {2016},
volume = {18},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/acs.orglett.5b03547},
number = {3},
pages = {516--519},
doi = {10.1021/acs.orglett.5b03547}
}
Cite this
MLA
Copy
Mahipal, Bodugam, et al. “A Pot-Economical Approach to the Total Synthesis of Sch-725674.” Organic Letters, vol. 18, no. 3, Jan. 2016, pp. 516-519. https://doi.org/10.1021/acs.orglett.5b03547.