Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction
Publication type: Journal Article
Publication date: 2018-01-10
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
29320204
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
A highly expedient protocol for a catalytic Appel-type dehydration of amides to nitriles has been developed that employs oxalyl chloride and triethylamine along with triphenylphosphine oxide as a catalyst. The reactions are usually complete in less than 10 min with only a 1 mol % catalyst loading. The reaction scope includes aromatic, heteroaromatic, and aliphatic amides, including derivatives of α-hydroxy and α-amino acids.
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Metrics
57
Total citations:
57
Citations from 2025:
3
(5.26%)
Cite this
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MLA
Cite this
GOST
Copy
Shipilovskikh S. A. et al. Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction // Organic Letters. 2018. Vol. 20. No. 3. pp. 728-731.
GOST all authors (up to 50)
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Shipilovskikh S. A., Vaganov V. Yu., Denisova E. I., Rubtsov A. E., Malkov A. V. Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction // Organic Letters. 2018. Vol. 20. No. 3. pp. 728-731.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.orglett.7b03862
UR - https://doi.org/10.1021/acs.orglett.7b03862
TI - Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction
T2 - Organic Letters
AU - Shipilovskikh, Sergei A
AU - Vaganov, Vladimir Yu
AU - Denisova, Elena I
AU - Rubtsov, Aleksandr E
AU - Malkov, A. V.
PY - 2018
DA - 2018/01/10
PB - American Chemical Society (ACS)
SP - 728-731
IS - 3
VL - 20
PMID - 29320204
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Shipilovskikh,
author = {Sergei A Shipilovskikh and Vladimir Yu Vaganov and Elena I Denisova and Aleksandr E Rubtsov and A. V. Malkov},
title = {Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction},
journal = {Organic Letters},
year = {2018},
volume = {20},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/acs.orglett.7b03862},
number = {3},
pages = {728--731},
doi = {10.1021/acs.orglett.7b03862}
}
Cite this
MLA
Copy
Shipilovskikh, Sergei A., et al. “Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction.” Organic Letters, vol. 20, no. 3, Jan. 2018, pp. 728-731. https://doi.org/10.1021/acs.orglett.7b03862.