Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus
Publication type: Journal Article
Publication date: 2018-10-17
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
30350678
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
Fungal glycolipids emmyguyacins A and B inhibit the pH-dependent conformational change of hemaglutinin A during replication of the Influenza virus. Herein, we report the first total synthesis and structure confirmation of emmyguyacins A and B. Our efficient route, which involves regioselective functionalization of trehalose, allows rapid access to adequate amounts of chemically pure emmyguyacin analogues including the desoxylate derivatives for SAR studies.
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13
Total citations:
13
Citations from 2024:
2
(15.38%)
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GOST
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Jana S., Sarpe V. A., Kulkarni S. S. Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus // Organic Letters. 2018. Vol. 20. No. 21. pp. 6938-6942.
GOST all authors (up to 50)
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Jana S., Sarpe V. A., Kulkarni S. S. Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus // Organic Letters. 2018. Vol. 20. No. 21. pp. 6938-6942.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acs.orglett.8b03073
UR - https://doi.org/10.1021/acs.orglett.8b03073
TI - Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus
T2 - Organic Letters
AU - Jana, Santanu
AU - Sarpe, Vikram A
AU - Kulkarni, Suvarn S.
PY - 2018
DA - 2018/10/17
PB - American Chemical Society (ACS)
SP - 6938-6942
IS - 21
VL - 20
PMID - 30350678
SN - 1523-7060
SN - 1523-7052
ER -
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BibTex (up to 50 authors)
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@article{2018_Jana,
author = {Santanu Jana and Vikram A Sarpe and Suvarn S. Kulkarni},
title = {Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus},
journal = {Organic Letters},
year = {2018},
volume = {20},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acs.orglett.8b03073},
number = {21},
pages = {6938--6942},
doi = {10.1021/acs.orglett.8b03073}
}
Cite this
MLA
Copy
Jana, Santanu, et al. “Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus.” Organic Letters, vol. 20, no. 21, Oct. 2018, pp. 6938-6942. https://doi.org/10.1021/acs.orglett.8b03073.