Biochemistry, volume 50, issue 40, pages 8692-8702
Mycoplasma gallisepticum Produces a Histone-like Protein That Recognizes Base Mismatches in DNA
Kamashev Dmitri
1, 2
,
Oberto Jacques
3
,
Gorbachev Alexey
1
,
Zhukova Yulia
1
,
Levitskii Sergei
1, 2
,
Mazur Alexey K.
4
,
Govorun Vadim M.
1, 2
3
Institut
de Génétique et Microbiologie, CNRS UMR 8621, Université Paris XI, Paris, France
|
4
UPR9080 CNRS, Université Paris Diderot, Sorbonne Paris Cité, Institut
de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, Paris
75005, France
|
Publication type: Journal Article
Publication date: 2011-09-14
Journal:
Biochemistry
Quartile SCImago
Q1
Quartile WOS
Q3
Impact factor: 2.9
ISSN: 00062960, 15204995
Biochemistry
Abstract
Mycoplasmas are the smallest known microorganisms, with drastically reduced genome sizes. One of the essential biochemical pathways lost in mycoplasmas is methylation-mediated DNA repair (MMR), which is responsible for correction of base substitutions, insertions, and deletions in both bacteria and higher organisms. We found that the histone-like protein encoded by the himA/hup_2 gene of Mycoplasma gallisepticum (mgHU) recognizes typical MMR substrates, in contrast to homologues from other species. The recognition of substitution mismatches is sequence-dependent, with affinities decreasing in the following order: CC > CT = TT > AA = AC. Insertions or deletions of one nucleotide are also specifically recognized with the following sequence-dependent preference: A = T > C. One-nucleotide lesions involving guanine are bound only weakly, and this binding is indistinguishable from binding to intact DNA. Although mgHU is dissimilar to Escherichia coli HU, expression in a slow-growing hupAB E. coli strain restores wild-type growth. The results indicate that mgHU executes all essential functions of bacterial architectural proteins. The origin and the possible role of enhanced specificity for typical MMR substrates are discussed.
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- We do not take into account publications that without a DOI.
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Kamashev D. et al. Mycoplasma gallisepticum Produces a Histone-like Protein That Recognizes Base Mismatches in DNA // Biochemistry. 2011. Vol. 50. No. 40. pp. 8692-8702.
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Kamashev D., Oberto J., Serebryakova M. V., Gorbachev A., Zhukova Y., Levitskii S., Mazur A. K., Govorun V. M. Mycoplasma gallisepticum Produces a Histone-like Protein That Recognizes Base Mismatches in DNA // Biochemistry. 2011. Vol. 50. No. 40. pp. 8692-8702.
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TY - JOUR
DO - 10.1021/bi2009097
UR - https://doi.org/10.1021%2Fbi2009097
TI - Mycoplasma gallisepticum Produces a Histone-like Protein That Recognizes Base Mismatches in DNA
T2 - Biochemistry
AU - Oberto, Jacques
AU - Zhukova, Yulia
AU - Levitskii, Sergei
AU - Mazur, Alexey K.
AU - Kamashev, Dmitri
AU - Serebryakova, M. V.
AU - Gorbachev, Alexey
AU - Govorun, Vadim M.
PY - 2011
DA - 2011/09/14 00:00:00
PB - American Chemical Society (ACS)
SP - 8692-8702
IS - 40
VL - 50
SN - 0006-2960
SN - 1520-4995
ER -
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@article{2011_Kamashev,
author = {Jacques Oberto and Yulia Zhukova and Sergei Levitskii and Alexey K. Mazur and Dmitri Kamashev and M. V. Serebryakova and Alexey Gorbachev and Vadim M. Govorun},
title = {Mycoplasma gallisepticum Produces a Histone-like Protein That Recognizes Base Mismatches in DNA},
journal = {Biochemistry},
year = {2011},
volume = {50},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021%2Fbi2009097},
number = {40},
pages = {8692--8702},
doi = {10.1021/bi2009097}
}
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Kamashev, Dmitri, et al. “Mycoplasma gallisepticum Produces a Histone-like Protein That Recognizes Base Mismatches in DNA.” Biochemistry, vol. 50, no. 40, Sep. 2011, pp. 8692-8702. https://doi.org/10.1021%2Fbi2009097.
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