Laboratory of Proteomic analysis

This study is aimed at studying the molecular mechanisms of epigenetic memory in the adhesive-invasive form of Escherichia coli (AIEC). Epigenetic memory is defined as the ability of an organism to register previous events at the level of gene expression without changing the DNA sequence. This phenomenon plays a significant role in the progression of many diseases, including inflammatory bowel diseases. The adhesive-invasive form of Escherichia coli (AIEC) is a bacterium significantly present in patients suffering from Crohn's disease. This microorganism has the ability to penetrate into intestinal cells and initiate an inflammatory process. In the context of the ongoing study, scientists are trying to figure out how AIEC "registers" previous interactions with the host immune system and the intestinal environment, and how this affects its ability to initiate inflammation. This may include analysis of various molecular mechanisms such as DNA modifications, changes in chromatin structure, and regulation of gene expression. Awareness of these mechanisms may contribute to the development of new strategies for the treatment of inflammatory bowel diseases such as Crohn's disease. This may involve the creation of drugs that affect the epigenetic memory of AIEC, or strategies that enhance the effectiveness of the immune system in the fight against this bacterium.