volume 22 issue 8 pages 935-943

Synthesis and biological activity of peptide antagonists of luliberin (luteinizing hormone-releasing hormone)

G. W. Moersch
M C Rebstock
E L Wittle
F J Tinney
E D Nicolaides
M. P. Hutt
T F Mich
J M Vandenbelt
R E Edgren
Publication typeJournal Article
Publication date1979-08-01
scimago Q1
wos Q1
SJR1.801
CiteScore11.5
Impact factor6.8
ISSN00222623, 15204804
PubMed ID:  385877
Drug Discovery
Molecular Medicine
Abstract
A series of des-His2 octa- and nonapeptide analogues of luliberin (luteinizing hormone-releasing hormone) with modifications in the 1 and 6 positions, and in some instances the 10 position, has been prepared. Some of these analogues are potent inhibitors of luliberin in vitro and in vivo. The use of ultraviolet absorption measurements for evaluating peptides containing tyrosine and tryptophan is described. An efficient synthesis of O-methyl-d-tyrosine is reported.
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GOST |
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GOST Copy
Moersch G. W. et al. Synthesis and biological activity of peptide antagonists of luliberin (luteinizing hormone-releasing hormone) // Journal of Medicinal Chemistry. 1979. Vol. 22. No. 8. pp. 935-943.
GOST all authors (up to 50) Copy
Moersch G. W., Rebstock M. C., Wittle E. L., Tinney F. J., Nicolaides E. D., Hutt M. P., Mich T. F., Vandenbelt J. M., Edgren R. E. Synthesis and biological activity of peptide antagonists of luliberin (luteinizing hormone-releasing hormone) // Journal of Medicinal Chemistry. 1979. Vol. 22. No. 8. pp. 935-943.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1021/jm00194a010
UR - https://doi.org/10.1021/jm00194a010
TI - Synthesis and biological activity of peptide antagonists of luliberin (luteinizing hormone-releasing hormone)
T2 - Journal of Medicinal Chemistry
AU - Moersch, G. W.
AU - Rebstock, M C
AU - Wittle, E L
AU - Tinney, F J
AU - Nicolaides, E D
AU - Hutt, M. P.
AU - Mich, T F
AU - Vandenbelt, J M
AU - Edgren, R E
PY - 1979
DA - 1979/08/01
PB - American Chemical Society (ACS)
SP - 935-943
IS - 8
VL - 22
PMID - 385877
SN - 0022-2623
SN - 1520-4804
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{1979_Moersch,
author = {G. W. Moersch and M C Rebstock and E L Wittle and F J Tinney and E D Nicolaides and M. P. Hutt and T F Mich and J M Vandenbelt and R E Edgren},
title = {Synthesis and biological activity of peptide antagonists of luliberin (luteinizing hormone-releasing hormone)},
journal = {Journal of Medicinal Chemistry},
year = {1979},
volume = {22},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://doi.org/10.1021/jm00194a010},
number = {8},
pages = {935--943},
doi = {10.1021/jm00194a010}
}
MLA
Cite this
MLA Copy
Moersch, G. W., et al. “Synthesis and biological activity of peptide antagonists of luliberin (luteinizing hormone-releasing hormone).” Journal of Medicinal Chemistry, vol. 22, no. 8, Aug. 1979, pp. 935-943. https://doi.org/10.1021/jm00194a010.