Chinikomycins A and B: Isolation, Structure Elucidation, and Biological Activity of Novel Antibiotics from a Marine Streptomyces sp. Isolate M045,1
Li Fuchao
1
,
Rajendra P Maskey
1
,
Song-Mei Qin
1
,
Isabel Sattler
1
,
Heinz H Fiebig
1
,
Armin Maier
1
,
Axel Zeeck
1
,
Hartmut Laatsch
1
Publication type: Journal Article
Publication date: 2005-02-26
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
15787434
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), and their structures were elucidated by a detailed interpretation of their spectra. Chinikomycins A (2a) and B (2b) are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains. They exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests.
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Metrics
101
Total citations:
101
Citations from 2024:
7
(6.93%)
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GOST
Copy
Fuchao L. et al. Chinikomycins A and B: Isolation, Structure Elucidation, and Biological Activity of Novel Antibiotics from a Marine Streptomyces sp. Isolate M045,1 // Journal of Natural Products. 2005. Vol. 68. No. 3. pp. 349-353.
GOST all authors (up to 50)
Copy
Fuchao L., Maskey R. P., Qin S., Sattler I., Fiebig H. H., Maier A., Zeeck A., Laatsch H. Chinikomycins A and B: Isolation, Structure Elucidation, and Biological Activity of Novel Antibiotics from a Marine Streptomyces sp. Isolate M045,1 // Journal of Natural Products. 2005. Vol. 68. No. 3. pp. 349-353.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/np030518r
UR - https://doi.org/10.1021/np030518r
TI - Chinikomycins A and B: Isolation, Structure Elucidation, and Biological Activity of Novel Antibiotics from a Marine Streptomyces sp. Isolate M045,1
T2 - Journal of Natural Products
AU - Fuchao, Li
AU - Maskey, Rajendra P
AU - Qin, Song-Mei
AU - Sattler, Isabel
AU - Fiebig, Heinz H
AU - Maier, Armin
AU - Zeeck, Axel
AU - Laatsch, Hartmut
PY - 2005
DA - 2005/02/26
PB - American Chemical Society (ACS)
SP - 349-353
IS - 3
VL - 68
PMID - 15787434
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2005_Fuchao,
author = {Li Fuchao and Rajendra P Maskey and Song-Mei Qin and Isabel Sattler and Heinz H Fiebig and Armin Maier and Axel Zeeck and Hartmut Laatsch},
title = {Chinikomycins A and B: Isolation, Structure Elucidation, and Biological Activity of Novel Antibiotics from a Marine Streptomyces sp. Isolate M045,1},
journal = {Journal of Natural Products},
year = {2005},
volume = {68},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/np030518r},
number = {3},
pages = {349--353},
doi = {10.1021/np030518r}
}
Cite this
MLA
Copy
Fuchao, Li, et al. “Chinikomycins A and B: Isolation, Structure Elucidation, and Biological Activity of Novel Antibiotics from a Marine Streptomyces sp. Isolate M045,1.” Journal of Natural Products, vol. 68, no. 3, Feb. 2005, pp. 349-353. https://doi.org/10.1021/np030518r.