Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources.
Nathaniel L Segraves
1
,
Sarah J Robinson
1
,
Daniel Garcia
1
,
Sadri A Said
1
,
Fu Xiong
1
,
Francis J Schmitz
1
,
Halina Pietraszkiewicz
1
,
Frederick A Valeriote
1
,
Phillip Crews
1
Publication type: Journal Article
Publication date: 2004-04-10
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
15165138
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
The fascaplysin class of compounds have been further investigated from six organisms consisting of four sponge collections (Fascaplysinopsis reticulata) and two tunicate collections (Didemnum sp.). This work is an extension of an earlier communication and reports the isolation of 12 new fascaplysin derivatives: 10-bromofascaplysin (7), 3,10-dibromofascaplysin (8), homofascaplysate A (9), homofascaplysin B-1 (11), 3-bromohomofascaplysins B (12), B-1 (13), and C (15), 7,14-dibromoreticulatine (17), reticulatol (20), 14-bromoreticulatol (21), and 3-bromosecofascaplysins A (22) and B (23), along with known compounds: fascaplysin (1), reticulatine (4), 3-bromofascaplysin (6), and homofascaplysin C (14). Selected compounds were screened in a cell-based cytotoxicity assay with compounds 1, 6, and fascaplysin A (24) also screened in the NCI 60 cell line panel. A biogenetic pathway for the brominated fascaplysins and brominated related alkaloids is proposed and discussed.
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121
Total citations:
121
Citations from 2024:
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(9.09%)
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GOST
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Segraves N. L. et al. Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. // Journal of Natural Products. 2004. Vol. 67. No. 5. pp. 783-792.
GOST all authors (up to 50)
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Segraves N. L., Robinson S. J., Garcia D., Said S. A., Xiong F., Schmitz F. J., Pietraszkiewicz H., Valeriote F. A., Crews P. Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. // Journal of Natural Products. 2004. Vol. 67. No. 5. pp. 783-792.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/np049935+
UR - https://doi.org/10.1021/np049935
TI - Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources.
T2 - Journal of Natural Products
AU - Segraves, Nathaniel L
AU - Robinson, Sarah J
AU - Garcia, Daniel
AU - Said, Sadri A
AU - Xiong, Fu
AU - Schmitz, Francis J
AU - Pietraszkiewicz, Halina
AU - Valeriote, Frederick A
AU - Crews, Phillip
PY - 2004
DA - 2004/04/10
PB - American Chemical Society (ACS)
SP - 783-792
IS - 5
VL - 67
PMID - 15165138
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex (up to 50 authors)
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@article{2004_Segraves,
author = {Nathaniel L Segraves and Sarah J Robinson and Daniel Garcia and Sadri A Said and Fu Xiong and Francis J Schmitz and Halina Pietraszkiewicz and Frederick A Valeriote and Phillip Crews},
title = {Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources.},
journal = {Journal of Natural Products},
year = {2004},
volume = {67},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/np049935 },
number = {5},
pages = {783--792},
doi = {10.1021/np049935+}
}
Cite this
MLA
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Segraves, Nathaniel L., et al. “Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources..” Journal of Natural Products, vol. 67, no. 5, Apr. 2004, pp. 783-792. https://doi.org/10.1021/np049935 .