Cytotoxic Cardenolide Glycosides of Roupellina (Strophanthus) boivinii from the Madagascar Rainforest
Sampada Karkare
1
,
Eba Adou
1
,
Shugeng Cao
1
,
Peggy Brodie
1
,
Allison L. Miller
1
,
N M Andrianjafy
1
,
J Razafitsalama
1
,
Rabodo Andriantsiferana
1
,
Vincent E. Rasamison
1
,
1
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis Missouri 63166-029 and B.P. 3391, Antananarivo, Madagascar, and Centre National dʼApplication des Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar
|
Publication type: Journal Article
Publication date: 2007-11-01
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
17988099
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
Bioassay-guided fractionation of an ethanol extract of Roupellina (Strophanthus) boivinii from the rainforest of Madagascar afforded the six new cardenolide glycosides boivinides 1-6, as well as the four known cardenolide glycosides digitoxigenin 3-O-[beta-D-glucopyrananosyl-(1-->4)-alpha-L-acofriopyranoside], corotoxigenin 3-O-beta-D-boivinoside, 17alpha-corotoxigenin 3-O-beta-D-sarmentoside, and uzarigenin 3-O-alpha-L-rhamnoside. The structures of these compounds were elucidated by various 1D and 2D NMR techniques. All new compounds showed significant antiproliferative activity against the A2780 human ovarian cancer cell line, with boivinide A being the most active at IC50 = 0.17 microM.
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Citations from 2024:
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GOST
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Karkare S. et al. Cytotoxic Cardenolide Glycosides of Roupellina (Strophanthus) boivinii from the Madagascar Rainforest // Journal of Natural Products. 2007. Vol. 70. No. 11. pp. 1766-1770.
GOST all authors (up to 50)
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Karkare S., Adou E., Cao S., Brodie P., Miller A. L., Andrianjafy N. M., Razafitsalama J., Andriantsiferana R., Rasamison V. E., Kingston D. Cytotoxic Cardenolide Glycosides of Roupellina (Strophanthus) boivinii from the Madagascar Rainforest // Journal of Natural Products. 2007. Vol. 70. No. 11. pp. 1766-1770.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/np070336n
UR - https://doi.org/10.1021/np070336n
TI - Cytotoxic Cardenolide Glycosides of Roupellina (Strophanthus) boivinii from the Madagascar Rainforest
T2 - Journal of Natural Products
AU - Karkare, Sampada
AU - Adou, Eba
AU - Cao, Shugeng
AU - Brodie, Peggy
AU - Miller, Allison L.
AU - Andrianjafy, N M
AU - Razafitsalama, J
AU - Andriantsiferana, Rabodo
AU - Rasamison, Vincent E.
AU - Kingston, David
PY - 2007
DA - 2007/11/01
PB - American Chemical Society (ACS)
SP - 1766-1770
IS - 11
VL - 70
PMID - 17988099
SN - 0163-3864
SN - 1520-6025
ER -
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BibTex (up to 50 authors)
Copy
@article{2007_Karkare,
author = {Sampada Karkare and Eba Adou and Shugeng Cao and Peggy Brodie and Allison L. Miller and N M Andrianjafy and J Razafitsalama and Rabodo Andriantsiferana and Vincent E. Rasamison and David Kingston},
title = {Cytotoxic Cardenolide Glycosides of Roupellina (Strophanthus) boivinii from the Madagascar Rainforest},
journal = {Journal of Natural Products},
year = {2007},
volume = {70},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/np070336n},
number = {11},
pages = {1766--1770},
doi = {10.1021/np070336n}
}
Cite this
MLA
Copy
Karkare, Sampada, et al. “Cytotoxic Cardenolide Glycosides of Roupellina (Strophanthus) boivinii from the Madagascar Rainforest.” Journal of Natural Products, vol. 70, no. 11, Nov. 2007, pp. 1766-1770. https://doi.org/10.1021/np070336n.