Characterization of the Congeners in the Lantibiotic NAI-107 Complex
S. Maffioli
1
,
Marianna Iorio
1
,
Margherita Sosio
1
,
Paolo Monciardini
1
,
Eleonora Gaspari
1
,
Stefano Donadio
1
1
NAICONS, Via Gaudenzio Fantoli 16/15, 20138, Milano, Italy
|
Publication type: Journal Article
Publication date: 2014-01-14
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
24422756
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
NAI-107, a lantibiotic produced by Microbispora sp. 107891, shows potent activity against multi-drug-resistant bacterial pathogens. It is produced as a complex of related molecules, which is unusual for ribosomally synthesized peptides. Here we describe the identification, characterization, and antibacterial activity of the congeners produced by Microbispora sp. 107891 and by the related Microbispora corallina NRRL 30420. These molecules differ by the presence of two, one, or zero hydroxyl groups at Pro-14, by the presence of a chlorine at Trp-4, and/or by the presence of a sulfoxide on the thioether of the first lanthionine.
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Total citations:
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Citations from 2024:
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(11.9%)
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BibTex |
MLA
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GOST
Copy
Maffioli S. et al. Characterization of the Congeners in the Lantibiotic NAI-107 Complex // Journal of Natural Products. 2014. Vol. 77. No. 1. pp. 79-84.
GOST all authors (up to 50)
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Maffioli S., Iorio M., Sosio M., Monciardini P., Gaspari E., Donadio S. Characterization of the Congeners in the Lantibiotic NAI-107 Complex // Journal of Natural Products. 2014. Vol. 77. No. 1. pp. 79-84.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/np400702t
UR - https://doi.org/10.1021/np400702t
TI - Characterization of the Congeners in the Lantibiotic NAI-107 Complex
T2 - Journal of Natural Products
AU - Maffioli, S.
AU - Iorio, Marianna
AU - Sosio, Margherita
AU - Monciardini, Paolo
AU - Gaspari, Eleonora
AU - Donadio, Stefano
PY - 2014
DA - 2014/01/14
PB - American Chemical Society (ACS)
SP - 79-84
IS - 1
VL - 77
PMID - 24422756
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Maffioli,
author = {S. Maffioli and Marianna Iorio and Margherita Sosio and Paolo Monciardini and Eleonora Gaspari and Stefano Donadio},
title = {Characterization of the Congeners in the Lantibiotic NAI-107 Complex},
journal = {Journal of Natural Products},
year = {2014},
volume = {77},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/np400702t},
number = {1},
pages = {79--84},
doi = {10.1021/np400702t}
}
Cite this
MLA
Copy
Maffioli, S., et al. “Characterization of the Congeners in the Lantibiotic NAI-107 Complex.” Journal of Natural Products, vol. 77, no. 1, Jan. 2014, pp. 79-84. https://doi.org/10.1021/np400702t.