Cycloartane Triterpenoids and Their Glycosides from the Rhizomes of Cimicifuga foetida
Ji Yong Chen
1, 2
,
Ping-Lin Li
1
,
Xu Li Tang
3
,
Shu-Jiang Wang
2
,
Yong-Tao Jiang
4
,
Li Shen
4
,
Ben Ming Xu
4
,
Yong-Liang Shao
5
,
Guoqiang Li
1
2
Shandong Luye Pharmaceutical Co., Ltd., Yantai 264003, People’s Republic of China
|
Тип публикации: Journal Article
Дата публикации: 2014-08-19
scimago Q1
wos Q1
БС1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
25136911
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Краткое описание
A phytochemical study on the rhizomes of Cimicifuga foetida resulted in the isolation of two new cycloartane triterpenoids (1 and 2), eight new cycloartane glycosides (3-10), and six known cycloartane glycoside analogues (11-16). The structures of 1-10 were determined by application of spectroscopic methods, with the absolute configuration of 1 determined by X-ray crystallography. Compounds 1-6, as three pairs of epimers at C-10 and C-24, belong to a seven-membered-ring variant of 9,10-seco-9,19-cycloartane triterpenoids, and glycosides 3-10 were found to be 3-O-β-D-xylopyranosides. The cytotoxicity of the isolates was evaluated against five selected human tumor cell lines, and the known compounds 15 and 16 showed cytotoxicity against the hepatocellular carcinoma SMMC-7721 cell line with IC50 values of 5.5 and 6.3 μM, respectively.
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Chen J. Y. et al. Cycloartane Triterpenoids and Their Glycosides from the Rhizomes of Cimicifuga foetida // Journal of Natural Products. 2014. Vol. 77. No. 9. pp. 1997-2005.
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Chen J. Y., Li P., Tang X. L., Wang S., Jiang Y., Shen L., Xu B. M., Shao Y., Li G. Cycloartane Triterpenoids and Their Glycosides from the Rhizomes of Cimicifuga foetida // Journal of Natural Products. 2014. Vol. 77. No. 9. pp. 1997-2005.
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TY - JOUR
DO - 10.1021/np500249v
UR - https://doi.org/10.1021/np500249v
TI - Cycloartane Triterpenoids and Their Glycosides from the Rhizomes of Cimicifuga foetida
T2 - Journal of Natural Products
AU - Chen, Ji Yong
AU - Li, Ping-Lin
AU - Tang, Xu Li
AU - Wang, Shu-Jiang
AU - Jiang, Yong-Tao
AU - Shen, Li
AU - Xu, Ben Ming
AU - Shao, Yong-Liang
AU - Li, Guoqiang
PY - 2014
DA - 2014/08/19
PB - American Chemical Society (ACS)
SP - 1997-2005
IS - 9
VL - 77
PMID - 25136911
SN - 0163-3864
SN - 1520-6025
ER -
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@article{2014_Chen,
author = {Ji Yong Chen and Ping-Lin Li and Xu Li Tang and Shu-Jiang Wang and Yong-Tao Jiang and Li Shen and Ben Ming Xu and Yong-Liang Shao and Guoqiang Li},
title = {Cycloartane Triterpenoids and Their Glycosides from the Rhizomes of Cimicifuga foetida},
journal = {Journal of Natural Products},
year = {2014},
volume = {77},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://doi.org/10.1021/np500249v},
number = {9},
pages = {1997--2005},
doi = {10.1021/np500249v}
}
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MLA
Скопировать
Chen, Ji Yong, et al. “Cycloartane Triterpenoids and Their Glycosides from the Rhizomes of Cimicifuga foetida.” Journal of Natural Products, vol. 77, no. 9, Aug. 2014, pp. 1997-2005. https://doi.org/10.1021/np500249v.